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PSD Antibodies
AND PSD ELISA kits, PSD Proteins
Many biological assays use antibodies to detect PSD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSD antibodies...
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PSD Infographic by Boster Bio
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PSD Overview
Facts about PH and SEC7 domain-containing protein 1.
PH and SEC7 domain-containing protein 1 (PSD)
Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity).
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Gene Information
| Human | |
|---|---|
| Gene Name: | PSD |
| Uniprot: | A5PKW4 |
| Entrez: | 5662 |
Family
| Belongs to: |
|---|
| PSD family |
Alternative Names
Exchange factor for ARF6; KIAA2011Pleckstrin homology and SEC7 domain-containing protein 1; pleckstrin and Sec7 domain containing; pleckstrin and Sec7 domain protein; PSD1PH and SEC7 domain-containing protein 1; TYLEFA6
Molecular Weight
Mass (kDA):
109.543 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q24.32 |
| Sequence: | 10; NC_000010.11 (102402617..102420164, complement) |
Tissue Specificity
Isoform 2 is expressed in the brain.
Subcellular Localizations
Cell membrane. Cell projection, ruffle membrane. Cleavage furrow. Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In later cytokinesis phases, fades away from the cleavage furrow and becomes uniformly distributed throughout the plasma membrane.
Diseases
- Glaucoma
- Depressive Disorder
- Intraocular Pressure Disorder
- Cerebrovascular Accident
- Glaucoma, Open-angle
- Nervousness
- Hypertensive Disease
- Disorder Of The Optic Nerve
- Neoplasms
- Ocular Hypertension
- Malignant Neoplasms
- Primary Open Angle Glaucoma
- Major Depressive Disorder
Interacting Proteins
- Usp9x
Pathways
- Localization
- Synaptic Transmission
- Transport
- Pathogenesis
- Flight
- Cell Adhesion
- Translation
- Endocytosis
- Penile Erection
- Secretion
- Brain Development
- Aging
- Coagulation
PTMs
- Phosphorylation
- Cleavage
- Ribosylation
- Dephosphorylation
- Oxidation
- Methylation
- Myristoylation
- Reduction
- Palmitoylation
- Decarboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSD
bosterbio.com/bosterbio-gene-info-cards/PSD
References
PMID: 9417912 by Perletti L., et al. Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains.
PMID: 23603394 by Ueda T., et al. EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.