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PROX1 Antibodies
AND PROX1 ELISA kits, PROX1 Proteins
Many biological assays use antibodies to detect PROX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PROX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PROX1 antibodies...
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PROX1 Infographic by Boster Bio
All PROX1 Products
Product
Figures
Specificity
Applications
Price
Anti-Prospero homeobox protein 1 PROX1 Antibody Picoband®
2 Citations 4 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA2229
100 μg/vial
Cat # PA2229
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01985-1
100 μg/vial
Cat # A01985-1
100 μg/vial
PROX1 Overview
Facts about Prospero homeobox protein 1.
Prospero homeobox protein 1 (PROX1)
Transcription factor involved in developmental processes like cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and acts as a key regulatory protein in neurogenesis and the evolution of the heart, eye lens, liver, pancreas and the lymphatic system.
Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes such as core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
Gene Information
| Human | |
|---|---|
| Gene Name: | PROX1 |
| Uniprot: | Q92786 |
| Entrez: | 5629 |
Family
| Belongs to: |
|---|
| Prospero homeodomain family |
Alternative Names
Homeobox prospero-like protein PROX1; prospero homeobox 1; prospero homeobox protein 1; prospero-related homeobox 1; Prox1; PROX-1
Molecular Weight
Mass (kDA):
83.203 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.3 |
| Sequence: | 1; NC_000001.11 (213983239..214041510) |
Tissue Specificity
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
Subcellular Localizations
Nucleus. RORG promotes its nuclear localization.
Diseases
- Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Lymphedema
- Carcinoma
- Tumor Angiogenesis
- Corneal Diseases
- Nervousness
- Diabetes Mellitus
- Tissue Adhesions
- Sarcoma
- Malignant Paraganglionic Neoplasm
- Kaposi Sarcoma
Interacting Proteins
- CTBP2
- HNF1A
- HNF4A
Pathways
- Lymphangiogenesis
- Cell Differentiation
- Cell Cycle
- Cell Proliferation
- Neurogenesis
- Angiogenesis
- Regeneration
- Eye Development
- Localization
- Lens Fiber Cell Differentiation
- Pathogenesis
- Liver Development
- Cell Growth
PTMs
- Methylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PROX1
bosterbio.com/bosterbio-gene-info-cards/PROX1
References
PMID: 8812486 by Zinovieva R.D., et al. Structure and chromosomal localization of the human homeobox gene Prox 1.
PMID: 22733308 by Elsir T., et al. Transcription factor PROX1: its role in development and cancer.
4 Publications of Boster PROX1 Antibodies & ELISA Kits
- PubMed ID: 33986371, Meng FW,Yu JT,Chen JY,Yang PF.New lymphatic cell formation is associated with da...
- PubMed ID: 32515838, Meng FW,Jing XN,Song GH,Jie LL,Shen FF.Prox1 induces new lymphatic vessel format...
- PubMed ID: 31960509, Meng FW,Liu FS,Liu WH,Li L,Jie LL.Formation of new lymphatic vessels in glioma: ...
- PubMed ID: 27203545, Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 a...
*More publications can be found for each product on its corresponding product page