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PRMT1 Antibodies
AND PRMT1 ELISA kits, PRMT1 Proteins
Many biological assays use antibodies to detect PRMT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRMT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRMT1 antibodies...
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PRMT1 Infographic by Boster Bio
All PRMT1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01417-3
100 μg/vial
Cat # A01417-3
100 μg/vial
Enzyme Activity, SDS-PAGE
$234
Cat # PROTQ9JIF0
Starting from 20ug
Cat # PROTQ9JIF0
Starting from 20ug
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01417-4
100 µg/vial
Cat # A01417-4
100 µg/vial
PRMT1 Overview
Facts about Protein arginine N-methyltransferase 1.
Protein arginine N-methyltransferase 1 (PRMT1)
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) that the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation.
Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, serve as an activator of estrogen receptor (ER)-mediated transactivation, play an integral role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by regulating p38 MAPK pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRMT1 |
| Uniprot: | Q99873 |
| Entrez: | 3276 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
ANM1; EC 2.1.1; EC 2.1.1.-; EC 2.1.1.125; EC 2.1.1.77; HCP1; Histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae); HMT1; HMT2; HRMT1L2; HRMT1L2HMT1 hnRNP methyltransferase-like 2; Interferon receptor 1-bound protein 4; IR1B4; IR1B4protein arginine N-methyltransferase 1; PRMT1; protein arginine methyltransferase 1
Molecular Weight
Mass (kDA):
42.462 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (49676166..49688450) |
Tissue Specificity
Widely expressed (PubMed:11097842). Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).
Subcellular Localizations
Nucleus. Nucleus, nucleoplasm. Cytoplasm. Cytoplasm, cytosol. Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Hepatitis
- Cardiovascular Diseases
- Heart Diseases
- Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
- Sarcoma
- Hypertensive Disease
Interacting Proteins
- CHTOP
- DCAF8
- DHX9
- EWSR1
- FAM9A
- FUS
- HABP4
- HIST1H4A
- HNRNPK
- HNRNPR
Pathways
- Methylation
- Localization
- Protein Methylation
- Translation
- Dna Repair
- Cell Cycle
- Rna Processing
- Chromatin Remodeling
- Cell Proliferation
- Histone Methylation
- Nuclear Export
- Pathogenesis
- Transport
PTMs
- Methylation
- Phosphorylation
- Acetylation
- Reduction
- Cleavage
- Myristoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRMT1
bosterbio.com/bosterbio-gene-info-cards/PRMT1
References
PMID: 9545638 by Scott H.S., et al. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2).
PMID: 8675017 by Nikawa J., et al. Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces cerevisiae ire15 mutant.