cGMP-dependent protein kinase 1 (PRKG1)

Serine/threonine protein kinase that acts as crucial mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins.

Numerous protein targets for PRKG1 phosphorylation are implicated in regulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 modulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of this NO-signaling pathway, and other processes involved in a number of facets of the CNS such as axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception.