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PRKDC Antibodies
AND PRKDC ELISA kits, PRKDC Proteins
Many biological assays use antibodies to detect PRKDC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRKDC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRKDC antibodies...
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PRKDC Infographic by Boster Bio
All PRKDC Products
Product
Figures
Specificity
Applications
Price
Human
IF, IHC, ICC, WB
$370
Cat # P00645
100 μl
Cat # P00645
100 μl
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00645
100 μl
Cat # M00645
100 μl
Human, Mouse
ELISA
$480
Cat # EKC1173
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1173
1 kit, containing one 96-well plate and all necessary reagents
PRKDC Overview
Facts about DNA-dependent protein kinase catalytic subunit.
DNA-dependent protein kinase catalytic subunit (PRKDC)
Serine/threonine-protein kinase that functions as a molecular sensor for DNA damage. Must be bound to DNA to state its catalytic properties.
The assembly of this DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRKDC |
| Uniprot: | P78527 |
| Entrez: | 5591 |
Family
| Belongs to: |
|---|
| PI3/PI4-kinase family |
Alternative Names
DNA-dependent protein kinase catalytic subunit-like; DNA-dependent protein kinase; DNA-PK catalytic subunit; DNAPK; DNAPKcs; DNA-PKcs; DNPK1; EC 2.7.11.1; HYRC; HYRC1; p350; p460; PRKDC; XRCC7
Molecular Weight
Mass (kDA):
469.089 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q11.21 |
| Sequence: | 8; NC_000008.11 (47773111..47960136, complement) |
Subcellular Localizations
Nucleus. Nucleus, nucleolus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Severe Combined Immunodeficiency
- Ataxia Telangiectasia
- Ataxia
- Immunologic Deficiency Syndromes
- Carcinoma
- Telangiectasis
- Malignant Neoplasm Of Breast
- Glioma
- Leukemia
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- AIRE
- AR
- DCLRE1C
- ETS1
- ETV1
- HOXB7
- IGFBP3
- MAPKAP1
- RARA
- SPI1
Pathways
- Dna Repair
- V(d)j Recombination
- Double-strand Break Repair
- Cell Cycle
- Cell Death
- Dna Replication
- Cell Cycle Arrest
- Hypersensitivity
- Localization
- Response To Ionizing Radiation
- Cell Proliferation
- Induction Of Apoptosis
- Pathogenesis
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Acetylation
- Ribosylation
- Ubiquitination
Research Areas
- Breast Cancer
- Cancer
- Checkpoint signaling
- DNA Double Strand Break Repair
- DNA Repair
- DNA replication, Transcription, Translation and Splicing
- Non-homologous end-joining
- Phospho-Specific
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKDC
bosterbio.com/bosterbio-gene-info-cards/PRKDC
References
PMID: 7671312 by Hartley K.O., et al. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
PMID: 11418067 by Anderson C.W., et al. Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J.