Perforin-1 Antibodies

AND PRF1 ELISA kits, Perforin-1 Proteins

Many biological assays use antibodies to detect Perforin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Perforin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Perforin-1 antibodies...

We validate the specificity of these antibodies to Perforin-1 by testing them on tissues known to express PRF1 positively and negatively. Browse below to find the PRF1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRF1 Infographic by Boster Bio

All PRF1 Products

Product

Figures

Specificity

Applications

Price

Anti-Perforin/PRF1 Antibody Picoband™

4 Q&As

Human

$370
Cat # PB9155
100 μg/vial

Anti-Perforin Prf1 Antibody (Monoclonal, CE2.10)

15 Q&As

Human, Mouse

IP, WB

$487
Cat # M01429
100μg/vial

Anti-Perforin Purified PRF1 Monoclonal Antibody

1 Citations

Cow, Human

Flow Cytometry, IP, IHC-P, IHC-F, ICC

$305
Cat # M01429-1
0.1 mg

Perforin (PRF1) (NM_005041) Human Over-expression Lysate

Human

$628
Cat # LS005551
100 µg

PRF1 Overview

Facts about Perforin-1.

PRF1 3D structure. Source: alphafold

Perforin-1 (PRF1)

Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells which are recognized as non-self by the immune system, e.

g. in transplant rejection or any forms of autoimmune disease.

Gene Information

Human
Gene Name:	PRF1
Uniprot:	P14222
Entrez:	5551

Family

Belongs to:

complement C6/C7/C8/C9 family

Alternative Names

Cytolysin; FLH2; HPLH2; HPLH2lymphocyte pore forming protein; Lymphocyte pore-forming protein; MGC65093; P1; P1PFN1; perforin 1 (pore forming protein); Perforin; perforin-1; PFP; PFPcytolysin; PRF1

Molecular Weight

Mass (kDA):
61.377 kDA

Genomic Context


Human

Location:	10q22.1
Sequence:	10; NC_000010.11 (70597348..70602788, complement)

Subcellular Localizations

Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes.