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PQBP1 Antibodies
AND PQBP1 ELISA kits, PQBP1 Proteins
Many biological assays use antibodies to detect PQBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PQBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PQBP1 antibodies...
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PQBP1 Overview
Facts about Polyglutamine-binding protein 1.
Polyglutamine-binding protein 1 (PQBP1)
Intrinsically disordered protein that serves as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron growth (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and modulates alternative splicing of goal pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308).
May suppress the capacity of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent way. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427).
Gene Information
| Human | |
|---|---|
| Gene Name: | PQBP1 |
| Uniprot: | O60828 |
| Entrez: | 10084 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
38 kDa nuclear protein containing a WW domain; MRX55; MRXS3; MRXS8; Npw38; NPW38mental retardation, X-linked 55; nuclear protein containing WW domain 38 kD; polyglutamine binding protein 1; Polyglutamine tract-binding protein 1; polyglutamine-binding protein 1; PQBP-1; RENS1; SHS; Sutherland-Haan X-linked mental retardation syndrome
Molecular Weight
Mass (kDA):
30.472 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.23 |
| Sequence: | X; NC_000023.11 (48897862..48903145) |
Tissue Specificity
Widely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes.
Subcellular Localizations
Nucleus. Nucleus speckle. Cytoplasmic granule. Colocalizes with SRSF2 in nuclear speckles (By similarity). Colocalized with POU3F2 (PubMed:10332029). Colocalized with ATXN1 in nuclear inclusion bodies (PubMed:12062018). Localizes to cytoplasmic stress granules (PubMed:21933836).
Diseases
- Microcephaly
- Dwarfism
- Neurodegenerative Disorders
- Ataxia, Spinocerebellar
- Mutation, Out-of-frame
- Ataxia
- Atrophy
- Congenital Abnormality
- Hypoplasia
- Paraplegia
- Genetic Diseases, X-linked
Interacting Proteins
- GOLGA2
- LZTS2
- MAPRE1
- WBP11
Pathways
- Cell Death
- Localization
- Pathogenesis
- Transport
- Translation
- Mrna Processing
- Gastrulation
- Cell Proliferation
- Neurogenesis
- Metaphase
- Neuron Death
- Nuclear Export
- Conjugation
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PQBP1
bosterbio.com/bosterbio-gene-info-cards/PQBP1
References
PMID: 10332029 by Waragai M., et al. PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival.
PMID: 10198427 by Komuro A., et al. Npw38, a novel nuclear protein possessing a WW domain capable of activating basal transcription.