PPP6C Antibodies

AND PPP6C ELISA kits, PPP6C Proteins

Many biological assays use antibodies to detect PPP6C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP6C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP6C antibodies...

We validate the specificity of these antibodies to PPP6C by testing them on tissues known to express PPP6C positively and negatively. Browse below to find the PPP6C antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PPP6C Infographic by Boster Bio

All PPP6C Products

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Anti-PPP6C Rabbit Monoclonal Antibody

Human

Flow Cytometry, IF, ICC, WB

$370
Cat # M05295
100 μl/vial

PPP6C Overview

Facts about Serine/threonine-protein phosphatase 6 catalytic subunit.

PPP6C 3D structure. Source: alphafold

Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C)

Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation.

N-terminal domain limits G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.

Gene Information

Human
Gene Name:	PPP6C
Uniprot:	O00743
Entrez:	5537

Family

Belongs to:

PPP phosphatase family

Alternative Names

EC 3.1.3.16; FLJ92648; MGC12249; PP6; PP6C; PPP6; protein phosphatase 6, catalytic subunit; serine/threonine protein phosphatase catalytic subunit; serine/threonine-protein phosphatase 6 catalytic subunit

Molecular Weight

Mass (kDA):
35.144 kDA

Genomic Context


Human

Location:	9q33.3
Sequence:	9; NC_000009.12 (125146573..125189939, complement)

Tissue Specificity

Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.

Subcellular Localizations

Mitochondrion. Cytoplasm.

Diseases

Neoplasms
Malignant Neoplasms
Melanoma
Celiac Disease
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Colonic Neoplasms
Malignant Tumor Of Colon
Neoplasm Invasiveness
Intestinal Diseases
Carcinoma
Nervousness
Colorectal Adenocarcinoma

Dysequilibrium Syndrome
Mesothelioma
Cell Invasion
Adenocarcinoma
Malignant Mesothelioma
Glioblastoma Multiforme
Central Nervous System Neoplasms

Interacting Proteins

ANKRD28
IGBP1
MAP3K7
PPP6R1
PPP6R2

PPP6R3
TIPRL

Pathways

Cell Cycle
Pathogenesis
Melanocyte Proliferation
Regulation Of Cell Cycle
Dna Replication
Cell Proliferation
Cell Growth

Localization
Cell Cycle Arrest

PTMs

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP6C

References

PMID: 9013334 by Bastians H., et al. The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation.

PMID: 10227379 by Filali M., et al. Identification of a type 6 protein Ser/Thr phosphatase regulated by interleukin-2 stimulation.