Serine/threonine-protein phosphatase 5 (PPP5C)

Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in various signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide including cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta in addition to oxidative and genotoxic stresses.

Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the law ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function.