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PPP1R8 Antibodies
AND PPP1R8 ELISA kits, PPP1R8 Proteins
Many biological assays use antibodies to detect PPP1R8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP1R8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP1R8 antibodies...
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PPP1R8 Infographic by Boster Bio
All PPP1R8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M05396
100 µl
Cat # M05396
100 µl
PPP1R8 Overview
Facts about Nuclear inhibitor of protein phosphatase 1.
Nuclear inhibitor of protein phosphatase 1 (PPP1R8)
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and might target PP-1 to RNA-associated substrates.
May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor.
Gene Information
| Human | |
|---|---|
| Gene Name: | PPP1R8 |
| Uniprot: | Q12972 |
| Entrez: | 5511 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
activator of RNA decay; ARD1; ard-1; ARD1nuclear inhibitor of protein phosphatase 1; NIPP1; NIPP1nuclear inhibitor of protein phosphatase-1; NIPP-1nuclear subunit of PP-1; PPP1R8; PRO2047; Protein phosphatase 1 regulatory inhibitor subunit 8; protein phosphatase 1 regulatory subunit 8; protein phosphatase 1, regulatory (inhibitor) subunit 8; RNase E
Molecular Weight
Mass (kDA):
38.479 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p35.3 |
| Sequence: | 1; NC_000001.11 (27830782..27851676) |
Tissue Specificity
Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells.
Subcellular Localizations
Nucleus. Nucleus speckle. Primarily, but not exclusively, nuclear.; [Isoform Gamma]: Cytoplasm. Found mainly in the cytoplasm.
Diseases
- Malignant Neoplasms
- Heart Failure
- Hypoxia
- Neoplasms
- Cardiomyopathy, Dilated
- Cardiomyopathies
- Multiple Acyl Coenzyme A Dehydrogenase Deficiency
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lymph Node
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Sarcoma
- Malignant Neoplasm Of Lung
Interacting Proteins
- APPBP2
- LRRK2
- PPP1CA
Pathways
- Localization
- Transport
- Translation
- Protein Phosphorylation
- Hyperphosphorylation
- Response To Hypoxia
- Cell Division
- Cell Proliferation
- Gene Silencing
- Mitosis
- Ectoderm Development
- Immune Response
- Platelet Activation
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP1R8
bosterbio.com/bosterbio-gene-info-cards/PPP1R8
References
PMID: 7524097 by Wang M., et al. ard-1: a human gene that reverses the effects of temperature- sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages.
PMID: 10103062 by Van Eynde A., et al. Organization and alternate splice products of the gene encoding nuclear inhibitor of protein phosphatase-1 (NIPP-1).