Protein phosphatase 1E Antibodies

AND PPM1E ELISA kits, Protein phosphatase 1E Proteins

Many biological assays use antibodies to detect Protein phosphatase 1E, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein phosphatase 1E in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein phosphatase 1E antibodies...

We validate the specificity of these antibodies to Protein phosphatase 1E by testing them on tissues known to express PPM1E positively and negatively. Browse below to find the PPM1E antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PPM1E Infographic by Boster Bio

All PPM1E Products

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Product

Figures

Specificity

Applications

Price

Anti-PPM1E Picoband® Antibody

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A08794
100 μg/vial

Anti-Protein phosphatase 1E PPM1E Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A08794-1
100ul

Anti-PPM1E Rabbit Monoclonal Antibody

Human

Flow Cytometry, WB

$370
Cat # M08794
100 μl/vial

PPM1E Overview

Facts about Protein phosphatase 1E.

PPM1E 3D structure. Source: alphafold

Protein phosphatase 1E (PPM1E)

Protein phosphatase that inactivates multifunctional CaM kinases like CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK.

May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).

Gene Information

Human
Gene Name:	PPM1E
Uniprot:	Q8WY54
Entrez:	22843

Family

Belongs to:

PP2C family

Alternative Names

ca(2+)/calmodulin-dependent protein kinase phosphatase N; CAMKN; CaMKP-N; caMKP-nucleus; DKFZp781F1422; KIAA1072; nuclear calmodulin-dependent protein kinase phosphatase; partner of PIX 1; partner of PIXA; partner of PIX-alpha; POPX1; PP2CH; protein phosphatase 1E (PP2C domain containing); protein phosphatase 1E; protein phosphatase, Mg2+/Mn2+ dependent, 1E

Molecular Weight

Mass (kDA):
83.952 kDA

Genomic Context


Human

Location:	17q22
Sequence:	17; NC_000017.11 (58755854..58985617)

Subcellular Localizations

Nucleus. Cytoplasm. A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus.

Diseases

Malignant Neoplasm Of Breast
Malignant Neoplasms
Neoplasms
Mammary Neoplasms
Reperfusion Injury
Schizophrenia
Myeloproliferative Disease
Myeloid Leukemia, Chronic
Diabetes Mellitus
Hepatomegaly
Mental Disorders

Mulibrey Nanism
Diabetes Mellitus, Non-insulin-dependent
Myeloid Leukemia
Cerebrovascular Accident
Leukemia
Dwarfism

Pathways

Translation
Gene Silencing
Aging
Histone Acetylation

PTMs

Phosphorylation

Dephosphorylation

Acetylation

Research Areas

Protein Phosphatase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPM1E

References

PMID: 11864573 by Koh C.-G., et al. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.

PMID: 16344560 by Kimura K., et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.