PPIL2 Antibodies

AND PPIL2 ELISA kits, PPIL2 Proteins

Many biological assays use antibodies to detect PPIL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPIL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPIL2 antibodies...

We validate the specificity of these antibodies to PPIL2 by testing them on tissues known to express PPIL2 positively and negatively. Browse below to find the PPIL2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PPIL2 Infographic by Boster Bio

All PPIL2 Products

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Product

Figures

Specificity

Applications

Price

Human PPIL2 Recombinant Protein

Enzyme Activity, SDS-PAGE

$265
Cat # PROTQ13356
Starting from 10ug

PPIL2 (NM_148176) Human Over-expression Lysate

Human

$960
Cat # LS023759
100 µg

Anti-PPIL2 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A11451-1
100 µg/vial

PPIL2 Overview

Facts about RING-type E3 ubiquitin-protein ligase PPIL2.

PPIL2 3D structure. Source: alphafold

RING-type E3 ubiquitin-protein ligase PPIL2 (PPIL2)

Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).

May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase without a peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).

Gene Information

Human
Gene Name:	PPIL2
Uniprot:	Q13356
Entrez:	23759

Family

Belongs to:

cyclophilin-type PPIase family

Alternative Names

CYC4; cyclophilin, 60kDa; cyclophilin-60; Cyclophilin-like protein Cyp-60; CYP60; Cyp-60; EC 5.2.1.8; FLJ39930; hCyP-60; MGC33174; MGC787; peptidylprolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase-like 2; peptidylprolyl isomerase (cyclophilin)-like 2; PPIase; Rotamase PPIL2

Molecular Weight

Mass (kDA):
58.823 kDA

Genomic Context


Human

Location:	22q11.21
Sequence:	22; NC_000022.11 (21665984..21700015)

Tissue Specificity

Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.