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- Table of Contents
Facts about Peptidyl-prolyl cis-trans isomerase H.
May play a role in the assembly of the U4/U5/U6 tri- snRNP complex, among the building blocks of the spliceosome. May act as a chaperone.
Human | |
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Gene Name: | PPIH |
Uniprot: | O43447 |
Entrez: | 10465 |
Belongs to: |
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cyclophilin-type PPIase family |
cyclophilin H; CYP20; CypH; CYPHpeptidyl prolyl isomerase H (cyclophilin H); EC 5.2.1.8; MGC5016; peptidyl-prolyl cis-trans isomerase H; peptidylprolyl isomerase H (cyclophilin H); PPIase H; Rotamase H; Small nuclear ribonucleoprotein particle-specific cyclophilin H; SnuCyp-20; USA-CyP SnuCyp-20; USA-CYPCYP-20; U-snRNP-associated cyclophilin SnuCyp-20; U-snRNP-associated cyclophilin SunCyp-20
Mass (kDA):
19.208 kDA
Human | |
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Location: | 1p34.2 |
Sequence: | 1; NC_000001.11 (42657770..42681654) |
Nucleus speckle. Cytoplasm. Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.
PMID: 9404889 by Horowitz D.S., et al. A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs.
PMID: 9570313 by Teigelkamp S., et al. The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins.