PPID Antibodies

Peptidyl-prolyl cis-trans isomerase D (PPID)

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and might thus assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to function as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes.

Different co- chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the capability to exert tissue-specific receptor action control. May have a preference for nitric oxide complexes and isn't found in glucocorticoid receptor complexes.

Gene Information

Human
Gene Name:	PPID
Uniprot:	Q08752
Entrez:	5481

Family

Belongs to:
cyclophilin-type PPIase family

Alternative Names

40 kDa peptidyl-prolyl cis-trans isomerase D; 40 kDa peptidyl-prolyl cis-trans isomerase; cyclophilin D; cyclophilin-40; Cyclophilin-related protein; CYP40; CYP-40cyclophilin 40; CYPD; EC 5.2.1.8; MGC33096; peptidyl-prolyl cis-trans isomerase D; peptidylprolyl isomerase D (cyclophilin D); peptidylprolyl isomerase D; PPIase D; Rotamase D

Molecular Weight

Mass (kDA):
40.764 kDA

Genomic Context

Human
Location:	4q32.1
Sequence:	4; NC_000004.12 (158709127..158723396, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.

Diseases

• Pituitary Diseases
• Horse Diseases
• Pituitary-dependent Cushing's Disease
• Malignant Neoplasms
• Nerve Degeneration
• Hyperplasia
• Neoplasms
• Cushing Syndrome
• Alzheimer's Disease
• Pain
• Edema
• Pain, Postoperative

• Adrenal Gland Hyperfunction
• Hypertrophy
• Parkinson Disease
• Infective Disorder
• Lameness, Animal
• Adenoma
• Physiological Stress

Interacting Proteins

• APP
• ATP5PO
• ILF2
• RACK1
• RPS3

• XRCC6

Pathways

• Cell Death
• Pathogenesis
• Protein Folding
• Transport
• Necrotic Cell Death
• Transposition
• Cell Proliferation
• Circadian Rhythm
• Gene Silencing
• Cellular Homeostasis
• Mitochondrial Outer Membrane Permeabilization
• Aging
• Proteolysis

• Protein Transport
• Virulence
• Muscle Atrophy
• Mitochondrial Translocation
• Reverse Transcription
• Cell Growth
• Mrna Processing

PTMs

• Nitration

• Carboxylation

• Deacetylation

Research Areas

• Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPID

Best Uses Of The PPID Marker

Using the PPID marker is essential for all researchers working with plants, animals, and microbial populations. Using this marker can help scientists identify the presence of a particular substance that causes plant toxicity. Scientists can use the marker in their experiments by submitting special samples and species. Scientists can also submit their results in applications and receive product credits for their work. The PPID marker can be used by scientists worldwide.

Anti-Bax (Apoptosis Marker) Monoclonal Antibody

This product identifies the Bax gene, which plays an important role in mitochondrial apoptosis. Under normal conditions, BAX is predominantly cytosolic and mediated by BCL2L1/BCL-XL. Under conditions of stress, BAX undergoes conformational changes, triggering the activation of the apoptotic pathway via CASP3.

This product has multiple functions, including regulating the expression of Bax and Bcl-2 proteins. These two proteins are critical for tumor growth, as both inhibit the other. BAX expression inhibits cancer cell growth and is therefore a critical part of any treatment strategy. Several studies have confirmed that ADM-NMC can significantly increase Bax expression while inhibiting Bcl-2 protein expression.

Another antibody to target Bax is the anti-Bax (Apoptose Marker) antibody. It is produced by Boster Bio and was previously used to investigate the effect of apoptosis. Antibodies to the Bax gene target apoptotic cells. When induced by oxidative stress, Bcl-2 is also activated.

Another anti-Bax monoclonal antibody from Boster Bio has been shown to induce apoptosis. This antibody is highly selective and inhibits Bcl-2 expression. Additionally, it increases Bax expression. As a result, it may enhance anti-tumor treatments. The results have been promising, and boster Bio is a leading company in biotechnology.

The anti-Bax (Apoptose Marker) antibody from Boster Bio is a highly sensitive and specific monoclonal antibody to Bax. Anti-Bax monoclonal antibody from Boster Bio was approved by the FDA in 2004. It is currently being used in immunohistochemical staining of tumor cells.

The Boster Anti-Bax monoclonal antibody from Boster Bio has a plethora of uses. It has been used for research on cancer cell death. In addition to its cytotoxic properties, it has anti-apoptotic activities. It also inhibits the activity of caspase-1 kinase, which is implicated in programmed cell death.

In an animal study, Boster Bio tested this monoclonal antibody against metastatic breast cancer. Mice that received two injections of the antibody received tumor-suppressed cells. Two weeks later, the mice were sacrificed, the tumors removed, and their weight measured. The results were remarkable, and suggest that the antibody may have potential for clinical use against solid tumors.

This monoclonal antibody has demonstrated significant anti-tumor activity against various malignancies. Its pricey nature, and the potential for side effects and resistance among some patients, make it an attractive alternative for cancer immunotherapy. Active immunization is an active immunization technique in which the patient is actively involved in the process of vaccination. This approach activates the patient's own immune system to fight cancer.