Periphilin-1 Antibodies

AND PPHLN1 ELISA kits, Periphilin-1 Proteins

Many biological assays use antibodies to detect Periphilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Periphilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Periphilin-1 antibodies...

We validate the specificity of these antibodies to Periphilin-1 by testing them on tissues known to express PPHLN1 positively and negatively. Browse below to find the PPHLN1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PPHLN1 Infographic by Boster Bio

All PPHLN1 Products

Product

Figures

Specificity

Applications

Price

Anti-Periphilin 1 PPHLN1 Antibody

3 Q&As

Human, Mouse

ELISA, IHC-P, WB

$399
Cat # A06996-1
100μl

Anti-PPHLN PPHLN1 Antibody

1 Q&As

Human, Mouse

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # A30527
100ul

PPHLN1 (NM_201438) Human Recombinant Protein

$1249
Cat # PROTQ8NEY8
20 µg

Anti-PPHLN1 Antibody (N-term)

Human

IF, WB

$298
Cat # A30527-1
80 µl

PPHLN1 (NM_201515) Human Over-expression Lysate

Human

$628
Cat # LS051535
100 µg

PPHLN1 Overview

Facts about Periphilin-1.

PPHLN1 3D structure. Source: alphafold

Periphilin-1 (PPHLN1)

Component of the HUSH complicated, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci full of H3K9me3 and is probably required to maintain transcriptional silencing by encouraging recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.

In the HUSH complex, contributes to the upkeep of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and modulates the cell cycle, probably through the HUSH complicated (PubMed:15474462, PubMed:17963697).

Gene Information

Human
Gene Name:	PPHLN1
Uniprot:	Q8NEY8
Entrez:	51535

Family

Belongs to:

No superfamily

Alternative Names

Gastric cancer antigen Ga50; HSPC232; MGC48786; periphilin 1; periphilin-1

Molecular Weight

Mass (kDA):
52.737 kDA

Genomic Context


Human

Location:	12q12
Sequence:	12; NC_000012.12 (42326126..42448621)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus. Cytoplasm. Chromosome. In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions (PubMed:12853457). Localizes to chromatin (PubMed:26022416).

Diseases

Congenital Nonbullous Ichthyosiform Erythroderma
Neurodegenerative Disorders
Ichthyoses
Congenital Ichthyosis
Parkinson Disease

Interacting Proteins

CCDC57
MTUS2
TSGA10

Pathways

Dna Replication
Cornification
Cell Cycle
Pathogenesis
Localization

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPHLN1

References

PMID: 12087473 by Line A., et al. Serological identification and expression analysis of gastric cancer- associated genes.

PMID: 12853457 by Kazerounian S., et al. Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope.