POU domain, class 2, transcription factor 1 (POU2F1)

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of these genes for some small nuclear RNAs (snRNA) and of genes like those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity).

In the event of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby allowing the transcription of the viral immediate early genes. .