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POLR2L Antibodies
AND POLR2L ELISA kits, POLR2L Proteins
Many biological assays use antibodies to detect POLR2L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POLR2L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POLR2L antibodies...
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POLR2L Infographic by Boster Bio
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POLR2L Overview
Facts about DNA-directed RNA polymerases I, II, and III subunit RPABC5.
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common part of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
Pol II is the central part of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other.
Gene Information
| Human | |
|---|---|
| Gene Name: | POLR2L |
| Uniprot: | P62875 |
| Entrez: | 5441 |
Family
| Belongs to: |
|---|
| archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family |
Alternative Names
DNA-directed RNA polymerase III subunit L; DNA-directed RNA polymerases I, II, and III subunit RPABC5; EC 2.7.7.6; hRPB7.6; hsRPB10b; polymerase (RNA) II (DNA directed) polypeptide L (7.6kD); polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; RBP10; RNA polymerase II 7.6 kDa subunit; RPABC5; RPB10 homolog; RPB10; RPB10beta; RPB7.6RNA polymerases I, II, and III subunit ABC5
Molecular Weight
Mass (kDA):
7.645 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.5 |
| Sequence: | 11; NC_000011.10 (839721..842529, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Vaccinia
- Rectal Carcinoma
- Malignant Neoplasms
- Hepatitis, Chronic
- Hepatitis
- Colonic Neoplasms
- Hepatitis C, Chronic
- Mammary Neoplasms
Interacting Proteins
- BANP
- COIL
- L3MBTL3
- PHC2
- REL
- RPAP1
- SPAG5
- THAP1
- ZBTB14
Pathways
- Reverse Transcription
- Localization
Research Areas
- DNA Repair
- DNA replication, Transcription, Translation and Splicing
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POLR2L
bosterbio.com/bosterbio-gene-info-cards/POLR2L
References
PMID: 8524256 by McKune K., et al. Six human RNA polymerase subunits functionally substitute for their yeast counterparts.
PMID: 7651387 by Shpakovski G.V., et al. Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae.