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DNA polymerase iota Antibodies
AND POLI ELISA kits, DNA polymerase iota Proteins
Many biological assays use antibodies to detect DNA polymerase iota, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA polymerase iota in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA polymerase iota antibodies...
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POLI Infographic by Boster Bio
All POLI Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # A01376-1
100 μg/vial
Cat # A01376-1
100 μg/vial
Human
IHC, WB
$523
Cat # M01376
100 µl
Cat # M01376
100 µl
POLI Overview
Facts about DNA polymerase iota.
DNA polymerase iota (POLI)
Error-prone DNA polymerase especially involved in DNA repair. Plays an essential role in translesion synthesis, in which the normal high-fidelity DNA polymerases can't move and DNA synthesis stalls.
Favors Hoogsteen base-pairing from the active website. Inserts the right base with high-fidelity reverse an adenosine template.
Gene Information
| Human | |
|---|---|
| Gene Name: | POLI |
| Uniprot: | Q9UNA4 |
| Entrez: | 11201 |
Family
| Belongs to: |
|---|
| DNA polymerase type-Y family |
Alternative Names
DNA polymerase iota; EC 2.7.7.7; eta2; polymerase (DNA directed) iota; RAD30 homolog B; RAD30Bpolymerase (DNA-directed), iota; RAD3OB
Molecular Weight
Mass (kDA):
83.006 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q21.2 |
| Sequence: | 18; NC_000018.10 (54269479..54321266) |
Tissue Specificity
Ubiquitous. Highly expressed in testis.
Subcellular Localizations
Nucleus. Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinogenesis
- Adenoma
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Squamous Cell Neoplasm
- Immunologic Deficiency Syndromes
- Influenza
- Adenocarcinoma
- Xeroderma
- Xeroderma Pigmentosum
- Inflammatory Response
Interacting Proteins
- DAZAP2
- NEDD8
- TMEM239
- TRAF6
- TRIM39
- UBC
- XRCC1
- ZBTB44
Pathways
- Translesion Synthesis
- Dna Repair
- Fertilization
- Photosynthesis
- Inflammatory Response
- Somatic Hypermutation Of Immunoglobulin Genes
- Regeneration
- Dna Replication
- Lactate Oxidation
- Strand Displacement
- Mitochondrial Depolarization
- Response To Heavy Metal
- Double-strand Break Repair
PTMs
- Deamination
Research Areas
- Chromatin Research
- DNA Polymerases
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POLI
bosterbio.com/bosterbio-gene-info-cards/POLI
References
PMID: 10458907 by McDonald J.P., et al. Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta.
PMID: 11013228 by Tissier A., et al. Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota.