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Prepronociceptin Antibodies

AND PNOC ELISA kits, Prepronociceptin Proteins

Many biological assays use antibodies to detect Prepronociceptin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prepronociceptin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prepronociceptin antibodies...

We validate the specificity of these antibodies to Prepronociceptin by testing them on tissues known to express PNOC positively and negatively. Browse below to find the PNOC antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PNOC Infographic by Boster Bio

PNOC protein infographic

All PNOC Products

Product

Figures

Specificity

Applications

Price

Anti-Prepronociceptin PNOC Antibody

Human

IF, WB

$405
Cat # A05605
100ul

Human PNOC Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ13519
Starting from 20ug

Nociceptin (PNOC) (NM_006228) Human Over-expression Lysate

Human

$628
Cat # LS005368
100 µg

PNOC Overview

Facts about Prepronociceptin.

PNOC 3D structure

PNOC 3D structure. Source: alphafold

Prepronociceptin (PNOC)

Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may work as a transmitter in the brain by modulating nociceptive and locomotor behavior.

May be involved in neuronal differentiation and development. .

Gene Information

Human
Gene Name:	PNOC
Uniprot:	Q13519
Entrez:	5368

Gene Information

Family

Belongs to:

opioid neuropeptide precursor family

Family

Alternative Names

nociceptin; nocistatin; OFQ; P; PPNOC; prepronociceptin; propronociceptin

Molecular Weight

Mass (kDA):
20.295 kDA

Molecular Weight

Genomic Context


Human

Location:	8p21.1
Sequence:	8; NC_000008.11 (28316979..28343355)

Tissue Specificity

Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.

Subcellular Localizations

Secreted.

Subcellular Localization

Diseases

Inhalation Exposure
Neoplasms
Pain
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Disease Of Adrenal Medulla
Mood Disorders
Substance-related Disorders
Malignant Neoplasm Of Breast
Neurodegenerative Disorders
Inflammatory Response
Carcinoma
Malignant Neoplasms

Cerebrovascular Accident
Mammary Neoplasms
Pertussis
Ganglioglioma
Status Epilepticus
Dysequilibrium Syndrome

Disease

Pathways

Neurogenesis
Autolysis
Pathogenesis
Inflammatory Response

Pathways

PTMs

Cleavage on pair of basic residues

Disulfide bond

Research Areas

Neuroscience
Signal Transduction

Research Areas

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PNOC

References

PMID: 8710928 by Mollereau C., et al. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene.

PMID: 8710930 by Nothacker H.-P., et al. Primary structure and tissue distribution of the orphanin FQ precursor.