This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Plexin-B3.
In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and mobile collapse in addition to inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. .
Human | |
---|---|
Gene Name: | PLXNB3 |
Uniprot: | Q9ULL4 |
Entrez: | 5365 |
Belongs to: |
---|
plexin family |
PLEXB3; Plexin B3; plexin-B3; PLEXR; PLXN6; PLXNB3
Mass (kDA):
206.847 kDA
Human | |
---|---|
Location: | Xq28 |
Sequence: | X; NC_000023.11 (153764196..153779346) |
Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines.
Cell membrane; Single-pass type I membrane protein. Colocalizes with RIT2/RIN at the plasma membrane.
PMID: 15184888 by Conrotto P., et al. Interplay between scatter factor receptors and B plexins controls invasive growth.
PMID: 15218527 by Artigiani S., et al. Plexin-B3 is a functional receptor for semaphorin 5A.