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- Table of Contents
Facts about Plexin-A1.
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D.
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin.
Human | |
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Gene Name: | PLXNA1 |
Uniprot: | Q9UIW2 |
Entrez: | 5361 |
Belongs to: |
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plexin family |
NOV; NOVP; Plexin A1; PLEXIN-A1; PLXN1; PLXNA1
Mass (kDA):
211.067 kDA
Human | |
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Location: | 3q21.3 |
Sequence: | 3; NC_000003.12 (126983259..127037392) |
Detected in fetal brain, lung, liver and kidney.
Cell membrane; Single-pass type I membrane protein.
PMID: 8570614 by Maestrini E., et al. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor.