Serine/threonine-protein kinase PLK2 (PLK2)

Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a particular motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1.

Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: necessary for overactivity-dependent backbone remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 resulting in their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their action.