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PLK1 Antibodies
AND PLK1 ELISA kits, PLK1 Proteins
Many biological assays use antibodies to detect PLK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLK1 antibodies...
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PLK1 Infographic by Boster Bio
All PLK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1476
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1476
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2581
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2581
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$523
Cat # M00182-1
100 µl
Cat # M00182-1
100 µl
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IP, IF, WB
$523
Cat # M00182-2
100 µl
Cat # M00182-2
100 µl
PLK1 Overview
Facts about Serine/threonine-protein kinase PLK1.
Serine/threonine-protein kinase PLK1 (PLK1)
Serine/threonine-protein kinase that performs many vital functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a particular motif recognized by the POLO box domains.
Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of this gamma-tubulin ring complex (gTuRC) to the centrosome, a significant step for spindle formation.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLK1 |
| Uniprot: | P53350 |
| Entrez: | 5347 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
cell cycle regulated protein kinase; EC 2.7.11; EC 2.7.11.21; PLK; PLK1; PLK-1; polo (Drosophia)-like kinase; polo like kinase; polo-like kinase 1polo-like kinase (Drosophila); Serine/threonine-protein kinase 13; serine/threonine-protein kinase PLK1; STPK13
Molecular Weight
Mass (kDA):
68.255 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p12.2 |
| Sequence: | 16; NC_000016.10 (23678889..23690367) |
Tissue Specificity
Placenta and colon.
Subcellular Localizations
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. localization at the centrosome starts at the G1/S transition (PubMed:24018379). During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGO1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. C
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Aneuploidy
- Adenocarcinoma
- Malignant Neoplasm Of Lung
- Genomic Instability
- Lymphoma
Interacting Proteins
- AURKA
- AXIN2
- BIRC6
- BLM
- BORA
- CDC25C
- CDC6
- CEP68
- CHEK2
- Dvl2
Pathways
- Mitosis
- Cell Cycle
- Localization
- Cytokinesis
- Cell Proliferation
- Cell Division
- Anaphase
- Chromosome Segregation
- Cell Cycle Arrest
- Spindle Assembly
- Metaphase
- Interphase
- Rna Interference
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Ubiquitination
- Methylation
- Phosphorothioation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Checkpoint signaling
- Core ESC-Like Genes
- DNA Double Strand Break Repair
- DNA Repair
- Mitotic Regulators
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLK1
bosterbio.com/bosterbio-gene-info-cards/PLK1
References
PMID: 8018557 by Hamanaka R., et al. Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase.
PMID: 7902533 by Lake R.J., et al. Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase.