Puratrophin-1 Antibodies

AND PLEKHG4 ELISA kits, Puratrophin-1 Proteins

Many biological assays use antibodies to detect Puratrophin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Puratrophin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Puratrophin-1 antibodies...

We validate the specificity of these antibodies to Puratrophin-1 by testing them on tissues known to express PLEKHG4 positively and negatively. Browse below to find the PLEKHG4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLEKHG4 Infographic by Boster Bio

All PLEKHG4 Products

Product

Figures

Specificity

Applications

Price

Anti-Puratrophin-1 PLEKHG4 Antibody

1 Q&As

Human, Monkey

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # A10252
100ul

Anti-Puratrophin 1 PLEKHG4 Antibody

Human, Monkey

ELISA, IHC, WB

$380
Cat # A10252-1
100ul

Anti-PLEKHG4 Antibody Picoband™

Human

ELISA, Flow Cytometry, WB

$370
Cat # A10252-2
100 µg/vial

PLEKHG4 Overview

Facts about Puratrophin-1.

PLEKHG4 3D structure. Source: alphafold

Puratrophin-1 (PLEKHG4)

Potential role in intracellular signaling and cytoskeleton dynamics in the Golgi. .

Gene Information

Human
Gene Name:	PLEKHG4
Uniprot:	Q58EX7
Entrez:	25894

Family

Belongs to:

No superfamily

Alternative Names

ARHGEF44; DKFZP434I216; PH domain-containing family G member 4; pleckstrin homology domain containing, family G (with RhoGef domain) member 4; Pleckstrin homology domain-containing family G member 4; PRTPHN1; puratrophin-1; Purkinje cell atrophy associated protein 1; Purkinje cell atrophy-associated protein 1; SCA4; spinocerebellar ataxia 4

Molecular Weight

Mass (kDA):
130.803 kDA

Genomic Context


Human

Location:	16q22.1
Sequence:	16; NC_000016.10 (67277820..67289500)

Tissue Specificity

Expressed in kidney, Leydig cells in the testis, epithelial cells in the prostate gland and Langerhans islet in the pancreas. Isoform 1 and isoform 3 are strongly expressed in Purkinje cells and to a lower extent in other neurons (at protein level). Widely expressed at low levels. More strongly expressed in testis and pancreas.

Diseases

Ataxia
Ataxia, Spinocerebellar
Cerebellar Ataxia
Atrophy
Neurodegenerative Disorders
Abnormal Degeneration
Dentatorubral-pallidoluysian Atrophy
Cerebellar Diseases
Trinucleotide Repeat Expansion
Spinocerebellar Ataxia Type 4
Peripheral Neuropathy

Sensorineural Hearing Loss (disorder)
Autoimmunity
Optic Atrophy
Mutation Abnormality
Neoplasm Metastasis
Malignant Neoplasm Of Breast

Interacting Proteins

MDFI

Pathways

Pathogenesis
Translation
Dna Repair

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEKHG4

References

PMID: 16001362 by Ishikawa K., et al. An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domains.

PMID: 17611710 by Amino T., et al. Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia.