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- Table of Contents
Facts about Plectin.
May be involved not only in the filaments network, but also in the regulation of the dynamics. Structural component of muscle.
Human | |
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Gene Name: | PLEC |
Uniprot: | Q15149 |
Entrez: | 5339 |
Belongs to: |
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plakin or cytolinker family |
EBS1; HD1; Hemidesmosomal protein 1; LGMD2Q; PCNplectin 1, intermediate filament binding protein, 500kD; PLEC1b; PLEC1EBSO; plectin 1, intermediate filament binding protein 500kDa; plectin; plectin-1; PLTNepidermolysis bullosa simplex 1 (Ogna)
Mass (kDA):
531.791 kDA
Human | |
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Location: | 8q24.3 |
Sequence: | 8; NC_000008.11 (143915153..143976800, complement) |
Widely expressed with highest levels in muscle, heart, placenta and spinal cord.
Cytoplasm, cytoskeleton. Cell junction, hemidesmosome.
PMID: 8633055 by Liu C.-G., et al. Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24).
PMID: 8698233 by McLean W.H.I., et al. Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization.