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- Table of Contents
, No Gclids
PLAT Antibodies
AND PLAT ELISA kits, PLAT Proteins
Many biological assays use antibodies to detect PLAT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLAT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLAT antibodies...
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PLAT Infographic by Boster Bio
All PLAT Products
Product
Figures
Specificity
Applications
Price
Human PLAT/TPA ELISA Kit PicoKine®
8 Citations 8 Q&As
Human
ELISA
$499
Cat # EK0897
96 wells/kit, with removable strips.
Cat # EK0897
96 wells/kit, with removable strips.
Anti-TPA Tissue Plasminogen Activator/PLAT Antibody Picoband®
1 Citations 1 Q&As
Human
WB
$370
Cat # PB9345
100 μg/vial
Cat # PB9345
100 μg/vial
Anti-PLAT/Tpa Rabbit Monoclonal Antibody
1 Citations 6 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # M02965
100 μl
Cat # M02965
100 μl
Human
ELISA
$500
Cat # EZ0897
For 5 plates, 96 wells each
Cat # EZ0897
For 5 plates, 96 wells each
Human, Mouse, Rat
Flow Cytometry, IHC, IHC-F, ICC, WB
$370
Cat # A02965-1
100 μg/vial
Cat # A02965-1
100 μg/vial
Human
ELISA
$499
Cat # FEK0897
96 wells/kit, with removable strips.
Cat # FEK0897
96 wells/kit, with removable strips.
PLAT Overview
Facts about Tissue-type plasminogen activator.
Tissue-type plasminogen activator (PLAT)
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing one Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays a significant role in tissue remodeling and degradation, in cell migration and several other physiopathological events.
Plays a direct role in facilitating neuronal migration. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PLAT |
| Uniprot: | P00750 |
| Entrez: | 5327 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
Alteplase; DKFZp686I03148; EC 3.4.21; EC 3.4.21.68; plasminogen activator, tissue type; plasminogen activator, tissue; PLAT; Reteplase; tissue plasminogen activator (t-PA); tissue-type plasminogen activator; TPA; T-PA; tPlasminogen Activator; t-Plasminogen Activator
Molecular Weight
Mass (kDA):
62.917 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p11.21 |
| Sequence: | 8; NC_000008.11 (42174718..42207565, complement) |
Tissue Specificity
Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Subcellular Localizations
Secreted, extracellular space.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Respiratory Distress Syndrome, Adult
- Inflammation
- Persistant Generalized Lymphadenopathy
- Liver Carcinoma
- Respiratory Distress
- Arteriosclerosis
- Thrombosis
- Dysequilibrium Syndrome
Pathways
- Coagulation
- Plasminogen Activation
- Fibrinolysis
- Localization
- Proteolysis
- Cell Migration
- Angiogenesis
- Cell Adhesion
- Platelet Activation
- Transport
- Platelet Aggregation
- Translation
- Cell Differentiation
PTMs
- Phosphorylation
- Cleavage
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLAT
bosterbio.com/bosterbio-gene-info-cards/PLAT
References
PMID: 6337343 by Pennica D., et al. Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.
PMID: 6089198 by Ny T., et al. The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.
10 Publications of Boster PLAT Antibodies & ELISA Kits
- PubMed ID: 10.1021/acsbiomaterials.7b00496, Improved Antithrombotic Function of Oriented Endothelial Cell Monolayer on Micro...
- PubMed ID: 10.1021/acsami.8b17530, Temperature-Gating Titania Nanotubes Regulate Migration of Endothelial Cells
- PubMed ID: 10.1016/j.joim.2020.04.004, Effective-constituent compatibility-based analysis of Bufei Yishen formula, a tr...
- PubMed ID: 10.1016/j.biologicals.2012.12.003, Oligodeoxyribonucleotides derived from salmon sperm DNA: An alternative to defib...
- PubMed ID: 10.1002/adhm.201601410, Mechanical Adaptability of the MMP‐Responsive Film Improves the Functionality ...
- PubMed ID: 10.1002/adhm.201601410, Mechanical Adaptability of the MMP‐Responsive Film Improves the Functionality ...
- PubMed ID: 10.1002/adhm.201601410, Mechanical Adaptability of the MMP‐Responsive Film Improves the Functionality ...
- PubMed ID: 34082810, Wang J,Li Y,Pan L,Li J,Yu Y,Liu B,Zubair M,Wei Y,Pillay B,Olaniran AO,Chiliza TE...
- PubMed ID: -, A novel silkworm pupae carboxymethyl chitosan inhibits mouse L929 fibroblast pro...
- PubMed ID: 28474486, Hu, M., Chang, H., Zhang, H., Wang, J., Lei, W.X., Li, B.C.,…, & Ji, J. (2017)...
*More publications can be found for each product on its corresponding product page