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Zinc finger protein PLAG1 Antibodies
AND PLAG1 ELISA kits, Zinc finger protein PLAG1 Proteins
Many biological assays use antibodies to detect Zinc finger protein PLAG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein PLAG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein PLAG1 antibodies...
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PLAG1 Overview
Facts about Zinc finger protein PLAG1.
Zinc finger protein PLAG1 (PLAG1)
Transcription factor whose activation results in up- regulation of target genes, such as IGFII, resulting in uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation have been observed. Other target genes like CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction.
Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is connected with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLAG1 |
| Uniprot: | Q6DJT9 |
| Entrez: | 5324 |
Family
| Belongs to: |
|---|
| krueppel C2H2-type zinc-finger protein family |
Alternative Names
COL1A2/PLAG1 fusion; Pleiomorphic adenoma gene 1 protein; pleiomorphic adenoma gene 1; SGPA; zinc finger protein PLAG1; ZNF912
Molecular Weight
Mass (kDA):
55.909 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q12.1 |
| Sequence: | 8; NC_000008.11 (56160909..56211327, complement) |
Tissue Specificity
Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors.
Subcellular Localizations
Nucleus. Strong nucleolar localization when sumoylation is inhibited.
Diseases
- Neoplasms
- Adenoma
- Mixed Salivary Gland Tumor
- Salivary Gland Neoplasms
- Cell Transformation, Neoplastic
- Salivary Gland Diseases
- Lipoblastoma
- Chromosomal Translocation
- Lipoma
- Malignant Neoplasms
- Malignant Paraganglionic Neoplasm
- Cytogenetic Abnormality
- Carcinoma
Pathways
- Pathogenesis
- Methylation
- Oncogenesis
- Cell Proliferation
- Localization
- Cell Cycle
- Interphase
- Dna Methylation
- Metaphase
- Cell Cycle Arrest
- Rna Interference
- Transport
- Cell Adhesion
PTMs
- Methylation
- Sumoylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLAG1
bosterbio.com/bosterbio-gene-info-cards/PLAG1
References
PMID: 9020842 by Kas K., et al. Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.
PMID: 9722527 by Kas K., et al. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.