PLA2G7 Antibodies

Platelet-activating factor acetylhydrolase (PLA2G7)

Modulates the activity of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates using a short residue at the sn-2 position.

It's inactive against long-chain phospholipids. .

Gene Information

Human
Gene Name:	PLA2G7
Uniprot:	Q13093
Entrez:	7941

Family

Belongs to:
AB hydrolase superfamily

Alternative Names

2-acetyl-1-alkylglycerophosphocholine esterase; EC 3.1.1; EC 3.1.1.47,1-alkyl-2-acetylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA(2); LDL-PLA2; lipoprotein-associated phospholipase A2; LpPLA2; Lp-PLA2; PAF acetylhydrolase; PAF-AH; PAFAHPAF 2-acylhydrolase; phospholipase A2, group VII (platelet-activating factor acetylhydrolase; PLA2G7; plasma); platelet-activating factor acetylhydrolase

Molecular Weight

Mass (kDA):
50.077 kDA

Genomic Context

Human
Location:	6p12.3
Sequence:	6; NC_000006.12 (46700558..46735836, complement)

Tissue Specificity

Plasma.

Subcellular Localizations

Secreted, extracellular space.

Diseases

• Coronary Artery Disease
• Cardiovascular Diseases
• Atherosclerosis
• Inflammation
• Coronary Heart Disease
• Heart Diseases
• Malignant Neoplasms
• Diabetes Mellitus
• Infarction
• Myocardial Infarction
• Dental Plaque
• Prostatic Neoplasms

• Malignant Neoplasm Of Prostate
• Obesity
• Neoplasms
• Dysequilibrium Syndrome
• Schizophrenia
• Hypertensive Disease
• Hyperlipidemia

Pathways

• Pathogenesis
• Aging
• Cell Death
• Immune Response
• Vasodilation
• Acute Inflammatory Response
• Cell Migration
• Programmed Cell Death
• Brain Development
• Chromosome Segregation
• Macrophage Activation
• Inflammatory Response

• Macrophage Differentiation
• Cell Cycle
• Cell Differentiation
• Cell Growth
• Rna Interference
• Secretion

PTMs

• Oxidation

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLA2G7

Boster Bio - Best Uses Of The PLA2G7 Marker

Boster Bio is the best place to start when you're looking for an antibody monoclonal. This review will provide details on this antibody as well as Boster Bio's multichannel pipettes. We'll also discuss the sizes of samples. For large samples, use a multichannel pipette. Boster will even credit you for your results!

Boster Bio Anti-CDw75 (B-Cell Marker) Monoclonal Antibody

If you are performing an investigation using flow cytometry techniques, you may be interested in purchasing the Boster Bio Anti-CDw75 (Cell Marker) monoclonal antibodies. They are well-cited and have a high affinity to particular cells and/or particles. Boster has monoclonal as well the polyclonal antibodies, which have high citations and have been in use for more than 25 years.

Although this monoclonal antibody is highly effective against B cells, it is not suitable for all patients. There are several reasons why some patients may become resistant to it. A rise in the number of regulatory proteins can result in a decrease in CDC activity. A decreased response to rituximab could result from a decreased ADCC activity. The decrease of CD20 protein expression may be due to post-transcriptional and translational mechanisms.

The following sequences can be found in the Boster Bio Anti CDw75 (b cell marker) antibody: SEQ ID No. 1: SEQ ID No. 2: CDRL1, CDRL2, CDRL3 and CDRh2. These sequences are responsible for the antibody's binding affinity B-Cell Marker-expressing cell.

The RIA method employs the use of a latex particle assay which determines the presence of anti-HBs antibodies in pre-vaccinated subjects. The latex particle assays however, found anti-HBs in prevaccinated subjects. The results were comparable to those of five commercial tests. It is interesting to note that these tests are less sensitive than the RIA method.

Producing monoclonal rabbit monoclonal antibody requires a number of steps. This includes immunization, isolation of plasma cells and screening, selection and the process of cloning. The most suitable clone is chosen to increase production and removal. Monoclonal antibodies can be produced in between 4 and 6 months. Boster Bio Anti-CDw75 (BCell Marker) monoclonal antibodies is the best choice for those who require antibodies to conduct your research.

The CD4+ T-cell count is a vital test for diagnosing HIV infection. It includes a variety cell subsets that include effector T cells central memory cells and naive cells. Each subset has various cytokines. For instance, CD4+ T cells contain cytokines that trigger the immune system.

Boster Bio Multichannel Pipettes

The MultiPette Plus series has four volumes that can overlap. This guarantees excellent precision and reproducibility while still delivering smooth pipe. The ergonomic handle can be placed in your right or left hand and has the ability to adjust the volume of the wheel and a volume lock. The pipette has a built-in certification of quality and can be purchased in one of four different price ranges: 0.1 mL, 0.25 mL, and 1 mL.

Because of its ergonomics, the xPIPETTE has been a popular choice in labs. This pipette can be used with Biotix's xTIP4 tips. Created to increase the efficiency of labs the pipette is ergonomic and comfortable for long-term use. Researchers will love its precision and precision. An electronic version of the pipette may be purchased.

Recommendations for sizes of samples

There are many ways to estimate the size of the sample for the PLA2G7 marker. The first step is to determine the number of patients with the specific level of expression for a gene. Then, use two-tailed chi-squared tests to assess the clinical characteristics between patients with different PLA2G7 expression levels. Then, use one-way ANOVAs or Student's t-tests to compare their survival outcomes. In the end, Kaplan-Meier survival curves were used to demonstrate the relationship between the expression level and OS.

A meta-analysis of a variety of variants within the PLA2G7 genetic gene has already identified them. These variants were not associated with coronary heart disease risk. Therefore the recommendation for the size of the sample for the PLA2G7 marker were based on the results of 10 studies. Although there is limited evidence on the sensitivity of the relationship between the variant and the risk of coronary heart disease, the relationship between the two genes is clear. Even when blood lipids are considered a covariable, the association remains constant.

PLA2G7 is a part of the arachidonic acids pathway , and has been linked to PCa that is invasive. Based on research that validated the marker could also function as a biomarker or a novel drug target. As of this writing, size guidelines for the PLA2G7 marker are based on research from only a few patients. This is based on Kruse and colleagues who conducted a study.