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, No Gclids
PLA2G4A Antibodies
AND PLA2G4A ELISA kits, PLA2G4A Proteins
Many biological assays use antibodies to detect PLA2G4A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLA2G4A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLA2G4A antibodies...
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PLA2G4A Infographic by Boster Bio
All PLA2G4A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # PA2047
100 μg/vial
Cat # PA2047
100 μg/vial
Human
ELISA
$750
Cat # EK2065
96 wells/kit, with removable strips.
Cat # EK2065
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA
$480
Cat # EKC1138
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1138
1 kit, containing one 96-well plate and all necessary reagents
PLA2G4A Overview
Facts about Cytosolic phospholipase A2.
Cytosolic phospholipase A2 (PLA2G4A)
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 place releasing arachidonic acid. Together with its lysophospholipid action, it is implicated in the initiation of the inflammatory reaction.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLA2G4A |
| Uniprot: | P47712 |
| Entrez: | 5321 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
calcium-dependent phospholipid-binding protein; cPLA2; cPLA2-alpha; lysophospholipase; MGC126350; phosphatidylcholine 2-acylhydrolase; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4A; PLA2G4cytosolic phospholipase A2
Molecular Weight
Mass (kDA):
85.239 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q31.1 |
| Sequence: | 1; NC_000001.11 (186828949..186988981) |
Tissue Specificity
Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
Subcellular Localizations
Cytoplasm. Cytoplasmic vesicle. Translocates to membrane vesicles in a calcium-dependent fashion.
Diseases
- Inflammation
- Schizophrenia
- Malignant Neoplasms
- Dysequilibrium Syndrome
- Asthma
- Endometrial Polyp
- Edema
- Neoplasms
- Arthritis
- Infarction
- Inflammatory Response
- Fibrosis
Pathways
- Secretion
- Pathogenesis
- Localization
- Embryo Implantation
- Parturition
- Inflammatory Response
- Fertilization
- Immune Response
- Reverse Transcription
- Cell Proliferation
- Ovulation
- Transport
- Apoptotic Cell Clearance
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLA2G4A
bosterbio.com/bosterbio-gene-info-cards/PLA2G4A
References
PMID: 1904318 by Clark J.D., et al. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)- dependent translocation domain with homology to PKC and GAP.
PMID: 1869522 by Sharp J., et al. Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2.