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- Table of Contents
Facts about Plakophilin-2.
Human | |
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Gene Name: | PKP2 |
Uniprot: | Q99959 |
Entrez: | 5318 |
Belongs to: |
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beta-catenin family |
ARVD9; MGC177501; plakophilin 2; plakophilin-2
Mass (kDA):
97.415 kDA
Human | |
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Location: | 12p11.21 |
Sequence: | 12; NC_000012.12 (32790746..32896846, complement) |
Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.
Nucleus. Cell junction, desmosome. Nuclear and associated with desmosomes.
PMID: 8922383 by Mertens C., et al. Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque.
PMID: 10374264 by Mertens C., et al. Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues.