Plakophilin-1 Antibodies

AND PKP1 ELISA kits, Plakophilin-1 Proteins

Many biological assays use antibodies to detect Plakophilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Plakophilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Plakophilin-1 antibodies...

We validate the specificity of these antibodies to Plakophilin-1 by testing them on tissues known to express PKP1 positively and negatively. Browse below to find the PKP1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PKP1 Infographic by Boster Bio

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PKP1 Overview

Facts about Plakophilin-1.

PKP1 3D structure. Source: alphafold

Plakophilin-1 (PKP1)

Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.

Gene Information

Human
Gene Name:	PKP1
Uniprot:	Q13835
Entrez:	5317

Family

Belongs to:

beta-catenin family

Alternative Names

B6PBand 6 protein; MGC138829; plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); plakophilin-1

Molecular Weight

Mass (kDA):
82.861 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (201283452..201332993)

Tissue Specificity

Isoform 2 is widely expressed. Isoform 1 is expressed in stratified squamous, complex, glandular duct and bladder epithelia.

Subcellular Localizations

[Isoform 1]: Nucleus. Cell junction, desmosome.; Nucleus.

Diseases

Dental Plaque
Tissue Adhesions
Ectodermal Dysplasia
Neoplasms
Carcinoma
Dermatologic Disorders
Dysplasia
Skin Diseases, Genetic
Malignant Squamous Cell Neoplasm
Malignant Neoplasms
Bulla
Dystrophy

Dystrophia Unguium
Adenocarcinoma
Hypotrichosis
Ectodermal Dysplasia/ Skin Fragility Syndrome
Hyperkeratosis
Neoplasm Metastasis
Palmoplantar Keratosis

Interacting Proteins

DSP
GTF2IRD1
KRT14
KRT18
KRT5

KRT8
TNS2
VIM

Pathways

Desmosome Assembly
Localization
Cell-cell Adhesion
Cell Adhesion
Dna Methylation
Methylation
Translation
Seed Germination
Cell Growth
Germination
Response To Wounding
Cell Migration
Proteolysis

Embryo Development
Actin Filament Organization
Keratinocyte Migration
Hair Cycle
Cell Cycle
Cell Motility
Cell Differentiation

PTMs

Methylation

Research Areas

Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKP1

References

PMID: 7527055 by Hatzfeld M., et al. Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family.

PMID: 9369526 by Schmidt A., et al. Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components.