This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
PKMYT1 Antibodies
AND PKMYT1 ELISA kits, PKMYT1 Proteins
Many biological assays use antibodies to detect PKMYT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PKMYT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PKMYT1 antibodies...
Previous: CCN4
Next: PIGQ
PKMYT1 Infographic by Boster Bio
All PKMYT1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$480
Cat # EKC1394
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1394
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M06247
100 µl
Cat # M06247
100 µl
PKMYT1 Overview
Facts about Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase.
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'.
Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect.
Gene Information
| Human | |
|---|---|
| Gene Name: | PKMYT1 |
| Uniprot: | Q99640 |
| Entrez: | 9088 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DKFZp547K1610; EC 2.7.11.1; FLJ20093; Myt1 kinase; MYT1membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; protein kinase, membrane associated tyrosine/threonine 1
Molecular Weight
Mass (kDA):
54.521 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (2972808..2980494, complement) |
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Nervousness
- Neoplasms, Neuroepithelial
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Ataxia
- Glioma
- Dysembryoplastic Neuroepithelial Tumor
- Myeloid Leukemia, Chronic
- Kidney Neoplasm
Interacting Proteins
- CCNB1
- CDK1
Pathways
- Cell Cycle
- Mitosis
- Cell Cycle Arrest
- M Phase
- Cell Proliferation
- Induction Of Apoptosis
- G2 Phase
- Localization
- Dna Replication
- S Phase
- Protein Phosphorylation
- Cell Adhesion
- Hyperphosphorylation
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKMYT1
bosterbio.com/bosterbio-gene-info-cards/PKMYT1
References
PMID: 9268380 by Booher R.N., et al. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.
PMID: 9001210 by Liu F., et al. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.