Fibrocystin Antibodies

AND PKHD1 ELISA kits, Fibrocystin Proteins

Many biological assays use antibodies to detect Fibrocystin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fibrocystin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fibrocystin antibodies...

We validate the specificity of these antibodies to Fibrocystin by testing them on tissues known to express PKHD1 positively and negatively. Browse below to find the PKHD1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PKHD1 Overview

Facts about Fibrocystin.

Fibrocystin (PKHD1)

May be required for proper bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. Might be a receptor protein that acts in collecting-duct and biliary differentiation.

Gene Information

Human
Gene Name:	PKHD1
Uniprot:	P08F94
Entrez:	5314

Family

Belongs to:

No superfamily

Alternative Names

polycystic kidney and hepatic disease 1 (autosomal recessive)

Molecular Weight

Mass (kDA):
446.702 kDA

Genomic Context


Human

Location:	6p12.3-p12.2
Sequence:	6; NC_000006.12 (51614685..52087625, complement)

Tissue Specificity

Predominantly expressed in fetal and adult kidney. In the kidney, it is found in the cortical and medullary collecting ducts. Also present in the adult pancreas, but at much lower levels. Detectable in fetal and adult liver. Rather indistinct signal in fetal brain.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere.

Diseases

Polycystic Kidney Diseases
Kidney Diseases
Autosomal Recessive Polycystic Kidney Disease
Liver Diseases
Polycystic Kidney, Autosomal Dominant
Cystic Kidney Diseases
Fibrosis
Hepatic Fibrosis
Cystic Disease -retired-
Kidney Failure, Chronic
Hypertensive Disease
Hereditary Diseases

Polycystic Liver Disease
Hypertension, Portal
Congenital Abnormality
Pathological Dilatation
Tissue Adhesions
Liver Cirrhosis

Interacting Proteins

CAMLG

Pathways

Pathogenesis
Localization
Cell Proliferation
Secretion
Cell Cycle
Cell Division
Dedifferentiation
Translation
Regulation Of Cell Proliferation
Transport
Cell Adhesion
Gene Silencing
Fertilization

Aging
Brain Development
Proteolysis
Hypersensitivity
Inflammatory Response
Cytoskeleton Organization
Cell Differentiation

PTMs

Phosphorylation
Cleavage
Glycosylation

Amidation
Methylation
Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKHD1

References

PMID: 11919560 by Ward C.J., et al. The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein.

PMID: 11898128 by Onuchic L.F., et al. PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like-plexin- transcription-factor domains and parallel beta-helix 1 repeats.