Polycystin-2 Antibodies

AND PKD2 ELISA kits, Polycystin-2 Proteins

Many biological assays use antibodies to detect Polycystin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Polycystin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Polycystin-2 antibodies...

We validate the specificity of these antibodies to Polycystin-2 by testing them on tissues known to express PKD2 positively and negatively. Browse below to find the PKD2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PKD2 Infographic by Boster Bio

All PKD2 Products

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PKD2 Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1471
1 kit, containing one 96-well plate and all necessary reagents

Anti-Polycystin 2/PKD2 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A00630-3
100 μg/vial

PKD2 (Phospho-Ser876) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC2207
1 kit, containing two 96-well plates and all necessary reagents

PKD2 Overview

Facts about Polycystin-2.

PKD2 3D structure. Source: alphafold

Polycystin-2 (PKD2)

Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that's activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Functions as a cation channel involved in fluid-flow mechanosensation from the primary cilium in renal epithelium (PubMed:18695040).

Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores in the endoplasmic reticulum (PubMed:11854751, PubMed:20881056).

Gene Information

Human
Gene Name:	PKD2
Uniprot:	Q13563
Entrez:	5311

Family

Belongs to:

polycystin family

Alternative Names

APKD2; Autosomal dominant polycystic kidney disease type II protein; MGC138466; MGC138468; PC2; Pc-2; PKD4; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; polycystin-2; polycystwin; R48321; transient receptor potential cation channel, subfamily P, member 2; TRPP2

Molecular Weight

Mass (kDA):
109.691 kDA

Genomic Context


Human

Location:	4q22.1
Sequence:	4; NC_000004.12 (88007635..88077779)

Tissue Specificity

Detected in fetal and adult kidney (PubMed:10770959). Detected at the thick ascending limb of the loop of Henle, at distal tubules, including the distal convoluted tubule and cortical collecting tubules, with weak staining of the collecting duct (PubMed:10770959). Detected on placenta syncytiotrophoblasts (at protein level) (PubMed:26269590). Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.

Subcellular Localizations

Cell projection, cilium membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus. PKD2 localization to the plasma and ciliary membranes requires PKD1. PKD1:PKD2 interaction is required to reach the Golgi apparatus form endoplasmic reticulum and then traffic to the cilia (By similarity). Retained in the endoplasmic reticulum by interaction with PACS1 and PACS2 (PubMed:15692563). Detected on kidney tubule basolateral membranes and basal c