Polycystin-1 Antibodies

AND PKD1 ELISA kits, Polycystin-1 Proteins

Many biological assays use antibodies to detect Polycystin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Polycystin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Polycystin-1 antibodies...

We validate the specificity of these antibodies to Polycystin-1 by testing them on tissues known to express PKD1 positively and negatively. Browse below to find the PKD1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PKD1 Infographic by Boster Bio

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PKD1 Overview

Facts about Polycystin-1.

Polycystin-1 (PKD1)

Part of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that's triggered by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). The two PKD1 and PKD2 are necessary for channel activity (PubMed:27214281).

Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation from the primary cilium in renal epithelium (By similarity).

Gene Information

Human
Gene Name:	PKD1
Uniprot:	P98161
Entrez:	5310

Family

Belongs to:

polycystin family

Alternative Names

Autosomal dominant polycystic kidney disease 1 protein; PBP; Pc-1; PKD1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease-associated protein; polycystin 1; Polycystin1; Polycystin-1; transient receptor potential cation channel, subfamily P, member 1; TRPP1

Molecular Weight

Mass (kDA):
462.529 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (2088708..2135898, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Endoplasmic reticulum. Golgi apparatus. PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain. PKD1:PKD2 interaction is required to reach the Golgi apparatus from endoplasmic reticulum and then traffic to the cilia (By similarity). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). Cell surface localization requires GANAB (PubMed:27259053).