Polycystin-1 Antibodies

Polycystin-1 (PKD1)

Part of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that's triggered by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). The two PKD1 and PKD2 are necessary for channel activity (PubMed:27214281).

Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation from the primary cilium in renal epithelium (By similarity).

Gene Information

Human
Gene Name:	PKD1
Uniprot:	P98161
Entrez:	5310

Family

Belongs to:
polycystin family

Alternative Names

Autosomal dominant polycystic kidney disease 1 protein; PBP; Pc-1; PKD1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease-associated protein; polycystin 1; Polycystin1; Polycystin-1; transient receptor potential cation channel, subfamily P, member 1; TRPP1

Molecular Weight

Mass (kDA):
462.529 kDA

Genomic Context

Human
Location:	16p13.3
Sequence:	16; NC_000016.10 (2088708..2135898, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Endoplasmic reticulum. Golgi apparatus. PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain. PKD1:PKD2 interaction is required to reach the Golgi apparatus from endoplasmic reticulum and then traffic to the cilia (By similarity). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). Cell surface localization requires GANAB (PubMed:27259053).

Diseases

• Polycystic Kidney Diseases
• Kidney Diseases
• Polycystic Kidney, Autosomal Dominant
• Kidney Failure, Chronic
• Kidney Failure
• Cystic Kidney Diseases
• Hereditary Diseases
• Hypertensive Disease
• Malignant Neoplasms
• Neoplasms
• Tissue Adhesions
• Tuberous Sclerosis

• Sclerosis
• Autosomal Recessive Polycystic Kidney Disease
• Cystic Disease -retired-
• Aneurysm
• Fibrosis
• Intracranial Aneurysm
• Liver Diseases

Interacting Proteins

• NPHP1
• PKD2

Pathways

• Localization
• Cell Proliferation
• Pathogenesis
• Transport
• Secretion
• Cell Migration
• Cell Growth
• Cell Cycle
• Cell Adhesion
• Translation
• Nuclear Export
• Angiogenesis
• Kidney Development

• Cell Death
• Epithelial Cell Proliferation
• Gene Conversion
• Cell-cell Adhesion
• Fertilization
• Cell-matrix Adhesion
• Insulin Secretion

PTMs

• Phosphorylation
• Cleavage
• Glycosylation
• Dephosphorylation
• Acetylation

• Methylation
• Ubiquitination
• Deacetylation
• Biotinylation
• Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKD1

Boster Bio: Best Uses of the PKD1 Marker

Scientists may have heard of Boster Bio - Best Uses and Applications of The PKD1Marker. But what is it exactly? This marker is not like any other gene markers. It is highly specific. Boster Bio scientists have the ability to use the product in special samples, species research, and applications. Scientists in the U.S. receive credit for using the product. They can also get product credits. It is also applicable to scientists all over the world.

PKD1/2/3 Cell-Based ELISA Kit

The PKD1/2/3 Cell-Based ELIISA Kit from Boster Bio provides a convenient, high-throughput solution to monitor the expression profile of PKD1/2/3 proteins in cultured cells. This kit can also be used for screening the effects of different activators and treatments. This kit is appropriate for researchers from both academia and industry. To learn more, read the following descriptions.