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Pituitary homeobox 3 Antibodies
AND PITX3 ELISA kits, Pituitary homeobox 3 Proteins
Many biological assays use antibodies to detect Pituitary homeobox 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pituitary homeobox 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pituitary homeobox 3 antibodies...
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PITX3 Infographic by Boster Bio
All PITX3 Products
Product
Figures
Specificity
Applications
Price
Anti-PITX3 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IP, WB
$370
Cat # M03453
100 μl/vial
Cat # M03453
100 μl/vial
PITX3 Overview
Facts about Pituitary homeobox 3.
Pituitary homeobox 3 (PITX3)
Transcriptional regulator which is essential for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. Besides its importance during development, it also has functions in the long-term survival and maintenance of the mdDA neurons.
Activates NR4A2/NURR1- mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state.
Gene Information
| Human | |
|---|---|
| Gene Name: | PITX3 |
| Uniprot: | O75364 |
| Entrez: | 5309 |
Family
| Belongs to: |
|---|
| paired homeobox family |
Alternative Names
CTPP4; Homeobox protein PITX3; MGC12766; paired-like homeodomain 3; Paired-like homeodomain transcription factor 3; pituitary homeobox 3; PTX3
Molecular Weight
Mass (kDA):
31.832 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q24.32 |
| Sequence: | 10; NC_000010.11 (102230189..102241512, complement) |
Tissue Specificity
Highly expressed in developing eye lens.
Subcellular Localizations
Nucleus.
Diseases
- Parkinson Disease
- Aphakia
- Cataract
- Nervousness
- Congenital Abnormality
- Pituitary Diseases
- Microphthalmos
- Nerve Degeneration
- Neurodegenerative Disorders
- Anterior Segment Mesenchymal Dysgenesis
- Schizophrenia
- Nervous System Disorder
Pathways
- Neuron Development
- Neuron Differentiation
- Eye Development
- Cell Differentiation
- Dopaminergic Neuron Differentiation
- Neurogenesis
- Cell Death
- Cell Cycle
- Cell Proliferation
- Localization
- Pathogenesis
- Transport
- Translation
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PITX3
bosterbio.com/bosterbio-gene-info-cards/PITX3
References
PMID: 9620774 by Semina E.V., et al. A novel homeobox gene PITX3 is mutated in families with autosomal- dominant cataracts and ASMD.
PMID: 15286169 by Berry V., et al. Recurrent 17 bp duplication in PITX3 is primarily associated with posterior polar cataract (CPP4).
1 Publications of Boster Pituitary homeobox 3 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.theriogenology.2016.01.004, BDNF-induced expansion of cumulus-oocyte complexes in pigs was mediated by micro...
*More publications can be found for each product on its corresponding product page