PITRM1 Antibodies

AND PITRM1 ELISA kits, PITRM1 Proteins

Many biological assays use antibodies to detect PITRM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PITRM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PITRM1 antibodies...

We validate the specificity of these antibodies to PITRM1 by testing them on tissues known to express PITRM1 positively and negatively. Browse below to find the PITRM1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PITRM1 Infographic by Boster Bio

All PITRM1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PITRM1 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A08969
100ul

Anti-PITRM1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A08969-1
100 μg/vial

PITRM1 (NM_014889) Human Over-expression Lysate

Human

$628
Cat # LS010531
100 µg

PITRM1 Overview

Facts about Presequence protease, mitochondrial.

PITRM1 3D structure. Source: alphafold

Presequence protease, mitochondrial (PITRM1)

Metalloendopeptidase of the mitochondrial matrix which functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325).

Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after little polar residues and before basic residues, but with no positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469).

Gene Information

Human
Gene Name:	PITRM1
Uniprot:	Q5JRX3
Entrez:	10531

Family

Belongs to:

peptidase M16 family

Alternative Names

EC 3.4.24; EC 3.4.24.-; hPreP; Metalloprotease 1; MGC138192; MGC141929; pitrilysin metallopeptidase 1; Pitrilysin metalloproteinase 1mitochondrial; PreP

Molecular Weight

Mass (kDA):
117.413 kDA

Genomic Context


Human

Location:	10p15.2
Sequence:	10; NC_000010.11 (3137727..3172841, complement)

Tissue Specificity

Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.

Subcellular Localizations

Mitochondrion matrix.

Diseases

Alzheimer's Disease
Cardiovascular Diseases
Obesity
Lymphomatoid Granulomatosis
Chronic Kidney Disease
Kidney Diseases
Kidney Failure, Chronic

Hypokinesia

Interacting Proteins

Pathways

Proteolysis
Glomerular Filtration

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PITRM1

References

PMID: 10360838 by Mzhavia N., et al. Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases.

PMID: 16849325 by Falkevall A., et al. Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP.