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- Table of Contents
Facts about Phosphatidylinositol 5-phosphate 4-kinase type-2 beta.
Human | |
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Gene Name: | PIP4K2B |
Uniprot: | P78356 |
Entrez: | 8396 |
Belongs to: |
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No superfamily |
1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; EC 2.7.1; EC 2.7.1.149; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; Phosphatidylinositol-5-phosphate 4-kinase type II beta; phosphatidylinositol-5-phosphate 4-kinase type-2 beta; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; PI(5)P 4-kinase type II beta; PI5P4KB; PIP4KII-beta; PIP5K2B; PIP5KIIB; PIP5KIIbeta; PTDINS(4)P-5-kinase; PtdIns(5)P-4-kinase isoform 2-beta
Mass (kDA):
47.378 kDA
Human | |
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Location: | 17q12 |
Sequence: | 17; NC_000017.11 (38765691..38799905, complement) |
Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.
Endoplasmic reticulum membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Associated with the plasma membrane and the endoplasmic reticulum.
PMID: 9038203 by Castellino A.M., et al. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5- kinase.
PMID: 20583997 by Bultsma Y., et al. PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.