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PIN1 Antibodies
AND PIN1 ELISA kits, PIN1 Proteins
Many biological assays use antibodies to detect PIN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIN1 antibodies...
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PIN1 Infographic by Boster Bio
All PIN1 Products
Product
Figures
Specificity
Applications
Price
Anti-Pin1 Antibody Picoband®
4 Q&As
Human, Monkey, Mouse, Rat
Flow Cytometry, WB
$370
Cat # PB9316
100 μg/vial
Cat # PB9316
100 μg/vial
Human, Monkey, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M00467-1
100 μg/vial
Cat # M00467-1
100 μg/vial
PIN1 Overview
Facts about Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr- Guru ) motifs. By causing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in several cellular processes (PubMed:21497122, PubMed:22033920, Ref.
21). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized.
Gene Information
| Human | |
|---|---|
| Gene Name: | PIN1 |
| Uniprot: | Q13526 |
| Entrez: | 5300 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
dod; EC 5.2.1.8; peptidylprolyl cis/trans isomerase, NIMA-interacting 1; peptidyl-prolyl cis/trans isomerase, NIMA-interacting; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; Pin1; PPIase Pin1; prolyl isomerase; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1; Rotamase Pin1; UBL5
Molecular Weight
Mass (kDA):
18.243 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (9835207..9849689) |
Tissue Specificity
The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells.
Subcellular Localizations
Nucleus. Nucleus speckle. Cytoplasm. Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122).
Diseases
- Malignant Neoplasms
- Neoplasms
- Alzheimer's Disease
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Neurodegenerative Disorders
- Nerve Degeneration
- Carcinoma
- Mammary Neoplasms
- Neurofibrillary Tangles
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Lung Neoplasms
Pathways
- Transport
- Auxin Transport
- Auxin Efflux
- Localization
- Cell Cycle
- Mitosis
- Pathogenesis
- Cell Proliferation
- Cell Division
- Cell Growth
- Endocytosis
- Gravitropism
- Cell Death
PTMs
- Phosphorylation
- Dephosphorylation
- Ubiquitination
- Cleavage
- Ribosylation
- Oxidation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIN1
bosterbio.com/bosterbio-gene-info-cards/PIN1
References
PMID: 8606777 by Lu K.P., et al. A human peptidyl-prolyl isomerase essential for regulation of mitosis.
PMID: 11470801 by Kamimoto T., et al. Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1.