PIGA Antibodies

AND PIGA ELISA kits, PIGA Proteins

Many biological assays use antibodies to detect PIGA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIGA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIGA antibodies...

We validate the specificity of these antibodies to PIGA by testing them on tissues known to express PIGA positively and negatively. Browse below to find the PIGA antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PIGA Infographic by Boster Bio

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Anti-PIGA Antibody

Human, Mouse

ELISA, WB

$380
Cat # A03695
100ul

PIGA Overview

Facts about Phosphatidylinositol N-acetylglucosaminyltransferase subunit A.

PIGA 3D structure. Source: alphafold

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIGA)

Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis. .

Gene Information

Human
Gene Name:	PIGA
Uniprot:	P37287
Entrez:	5277

Family

Belongs to:

glycosyltransferase group 1 family

Alternative Names

class A GlcNAc-inositol phospholipid assembly protein; EC 2.4.1.198; GlcNAc-PI synthesis protein; GPI anchor biosynthesis; GPI3; phosphatidylinositol glycan anchor biosynthesis, class A; phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria); phosphatidylinositol N-acetylglucosaminyltransferase subunit A; Phosphatidylinositol-glycan biosynthesis class A protein; phosphatidylinositol-glycan biosynthesis, class A protein; PIG-A

Molecular Weight

Mass (kDA):
54.127 kDA

Genomic Context


Human

Location:	Xp22.2
Sequence:	X; NC_000023.11 (15319451..15335554, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Paroxysmal Nocturnal Hemoglobinuria
Hemoglobinuria
Hemoglobinuria, Paroxysmal
Anemia
Hemolysis (disorder)
Aplastic Anemia
Intravascular Hemolysis
Thrombosis
Pancytopenia
Anemia, Hemolytic
Hematological Disease

Neoplasms
Autoimmune Reaction
Acquired Hemolytic Anemia
Tissue Adhesions
Hereditary Diseases
Autoimmune Diseases

Pathways

Pathogenesis
Complement Activation
Localization
Cell Death
Transport
Cell Adhesion
Blood Coagulation
Quorum Sensing
Convergent Extension
Eggshell Formation
Protein Secretion
Oxidative Phosphorylation

Palate Development
Virulence
Coagulation
Cell Cycle
Rna Interference
Secretion

PTMs

Gpi Anchoring
Phosphorylation

Cleavage
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIGA

References

PMID: 7680492 by Miyata T., et al. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis.

PMID: 8081362 by Bessler M., et al. Genomic organization of the X-linked gene (PIG-A) that is mutated in paroxysmal nocturnal haemoglobinuria and of a related autosomal pseudogene mapped to 12q21.