PICALM Antibodies

Phosphatidylinositol-binding clathrin assembly protein (PICALM)

Assembly protein recruitment clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage.

Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. .

Gene Information

Human
Gene Name:	PICALM
Uniprot:	Q13492
Entrez:	8301

Family

Belongs to:
PICALM/SNAP91 family

Alternative Names

CALMclathrin assembly lymphoid-myeloid leukemia; Clathrin assembly lymphoid myeloid leukemia protein; CLTHphosphatidylinositol-binding clathrin assembly protein; LAP; phosphatidylinositol binding clathrin assembly protein

Molecular Weight

Mass (kDA):
70.755 kDA

Genomic Context

Human
Location:	11q14.2
Sequence:	11; NC_000011.10 (85957175..86069860, complement)

Tissue Specificity

Expressed in all tissues examined.

Subcellular Localizations

Cell membrane. Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119).

Diseases

• Alzheimer's Disease
• Leukemia
• Myeloid Leukemia
• Dementia
• Leukemia, Myelocytic, Acute
• Impaired Cognition
• Neurodegenerative Disorders
• Acute Lymphocytic Leukemia
• Lymphoma
• Chromosomal Translocation
• Leukemogenesis
• Nerve Degeneration

• Mild Cognitive Disorder
• Malignant Paraganglionic Neoplasm
• Cytogenetic Abnormality
• Malignant Neoplasms
• Atrophy
• Precursor T-cell Lymphoblastic Leukemia-lymphoma
• Dental Plaque

Interacting Proteins

• FHL2

Pathways

• Endocytosis
• Pathogenesis
• Clathrin-mediated Endocytosis
• Aging
• Transport
• Localization
• Cognition
• Translation
• Secretory Pathway
• Intracellular Transport
• Nuclear Export
• Exocytosis
• Methylation

• Rna Interference
• Cell Adhesion
• Proteolysis
• Inflammatory Response
• Sensitization
• Cell Communication
• Cell Proliferation

PTMs

• Phosphorylation

• Cleavage

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PICALM

Best Uses Of The PICALM Marker

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Historial background

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Current projects

There are numerous opportunities for PICALM to influence the pathogenesis of AD. A prominent hypothesis holds that PICALM regulates the internalization of APP and production of Ab. Additionally, PICALM may act through its role in endocytosis and trafficking. This is a promising line of research. More studies are needed to understand how this protein influences the pathogenesis of AD. To date, researchers have been able to identify PICALM-mediated processes that affect APP internalization and Ab production.

Because PICALM is not present in the perinuclear region, it is not known whether it directly influences clathrin targeting. However, it likely has a role in regulating trafficking between early endosomes and the transgolgi network. As there are several proteins involved in this process, depletion of PICALM may affect multiple targets. Moreover, PICALM is involved in the endocytosis of R-SNAREs, which are soluble NSF attachment protein receptors that are essential for their fusion with endosomes and the plasma membrane.

Products offered

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