PICALM Antibodies

AND PICALM ELISA kits, PICALM Proteins

Many biological assays use antibodies to detect PICALM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PICALM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PICALM antibodies...

We validate the specificity of these antibodies to PICALM by testing them on tissues known to express PICALM positively and negatively. Browse below to find the PICALM antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PICALM Infographic by Boster Bio

All PICALM Products

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Product

Figures

Specificity

Applications

Price

Anti-PICALM Picoband® Antibody

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A02053-1
100 μg/vial

PICALM (NM_007166) Human Over-expression Lysate

Human

$628
Cat # LS008301
100 µg

Anti-PICALM Rabbit Monoclonal Antibody

Human

IF, IHC, ICC, WB

$370
Cat # M02053
100 µl/vial

PICALM Overview

Facts about Phosphatidylinositol-binding clathrin assembly protein.

PICALM 3D structure. Source: alphafold

Phosphatidylinositol-binding clathrin assembly protein (PICALM)

Assembly protein recruitment clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage.

Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. .

Gene Information

Human
Gene Name:	PICALM
Uniprot:	Q13492
Entrez:	8301

Family

Belongs to:

PICALM/SNAP91 family

Alternative Names

CALMclathrin assembly lymphoid-myeloid leukemia; Clathrin assembly lymphoid myeloid leukemia protein; CLTHphosphatidylinositol-binding clathrin assembly protein; LAP; phosphatidylinositol binding clathrin assembly protein

Molecular Weight

Mass (kDA):
70.755 kDA

Genomic Context


Human

Location:	11q14.2
Sequence:	11; NC_000011.10 (85957175..86069860, complement)

Tissue Specificity

Expressed in all tissues examined.

Subcellular Localizations

Cell membrane. Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119).

Diseases

Alzheimer's Disease
Leukemia
Myeloid Leukemia
Dementia
Leukemia, Myelocytic, Acute
Impaired Cognition
Neurodegenerative Disorders
Acute Lymphocytic Leukemia
Lymphoma
Chromosomal Translocation
Leukemogenesis
Nerve Degeneration

Mild Cognitive Disorder
Malignant Paraganglionic Neoplasm
Cytogenetic Abnormality
Malignant Neoplasms
Atrophy
Precursor T-cell Lymphoblastic Leukemia-lymphoma
Dental Plaque

Interacting Proteins

FHL2

Pathways

Endocytosis
Pathogenesis
Clathrin-mediated Endocytosis
Aging
Transport
Localization
Cognition
Translation
Secretory Pathway
Intracellular Transport
Nuclear Export
Exocytosis
Methylation

Rna Interference
Cell Adhesion
Proteolysis
Inflammatory Response
Sensitization
Cell Communication
Cell Proliferation

PTMs

Phosphorylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PICALM

References

PMID: 8643484 by Dreyling M.H., et al. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.

PMID: 9737689 by Silliman C.C., et al. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10- CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14- q21) suggests a potential role for truncated AF10 polypeptides.