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PHLPP1 Antibodies
AND PHLPP1 ELISA kits, PHLPP1 Proteins
Many biological assays use antibodies to detect PHLPP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHLPP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHLPP1 antibodies...
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PHLPP1 Overview
Facts about PH domain leucine-rich repeat-containing protein phosphatase 1.
PH domain leucine-rich repeat-containing protein phosphatase 1 (PHLPP1)
Mediates dephosphorylation in the C-terminal domain hydrophobic motif of all members of the AGC Ser/Thr protein kinase family; especially acts on'Ser-473' of AKT2 and AKT3,'Ser-660' of PRKCB and'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a significant role in regulating Akt signaling in hippocampal neurons (By similarity).
Akt modulates the balance between cell survival and apoptosis by means of a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of'Ser-473' of Akt triggers apoptosis and suppression of tumor development.
Gene Information
| Human | |
|---|---|
| Gene Name: | PHLPP1 |
| Uniprot: | O60346 |
| Entrez: | 23239 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 3.1.3.16; hSCOP; KIAA0606; MGC161555; PH domain and leucine rich repeat protein phosphatase 1; PH domain and leucine rich repeat protein phosphatase; PH domain leucine-rich repeat-containing protein phosphatase 1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats)member 1; Pleckstrin homology domain-containing family E member 1; PLEKHE1; SCN circadian oscillatory protein; SCOPPH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein
Molecular Weight
Mass (kDA):
184.672 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q21.33 |
| Sequence: | 18; NC_000018.10 (62715445..62980433) |
Tissue Specificity
In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 78% of tested tumors (at protein level). Ubiquitously expressed in non-cancerous tissues.
Subcellular Localizations
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells.; [Isoform 2]: Cell membrane.
Diseases
- Malignant Neoplasms
- Neoplasms
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Malignant Tumor Of Colon
- Diabetes Mellitus
- Leukemia
- Colorectal Cancer
- Chronic Lymphocytic Leukemia
- Glioblastoma
- Lymphoid Leukemia
Interacting Proteins
- SCRIB
- Scrib
- SLC9A3R1
Pathways
- Cell Proliferation
- Cell Growth
- Translation
- Cell Death
- Circadian Rhythm
- Localization
- Cell Cycle
- Transport
- Hyperphosphorylation
- Cellular Homeostasis
- Aging
PTMs
- Phosphorylation
Research Areas
- Cancer
- Protein Phosphatase
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHLPP1
bosterbio.com/bosterbio-gene-info-cards/PHLPP1
References
PMID: 15808505 by Gao T., et al. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
PMID: 17386267 by Brognard J., et al. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.