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PHLDA2 Antibodies
AND PHLDA2 ELISA kits, PHLDA2 Proteins
Many biological assays use antibodies to detect PHLDA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHLDA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHLDA2 antibodies...
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PHLDA2 Overview
Facts about Pleckstrin homology-like domain family A member 2.
Pleckstrin homology-like domain family A member 2 (PHLDA2)
Plays a role in regulating placenta development. May act via its PH domain name that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).
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Gene Information
| Human | |
|---|---|
| Gene Name: | PHLDA2 |
| Uniprot: | Q53GA4 |
| Entrez: | 7262 |
Family
| Belongs to: |
|---|
| PHLDA2 family |
Alternative Names
Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; BWR1Cp17-Beckwith-Wiedemann region 1 C; HLDA2BRW1C; Imprinted in placenta and liver protein; IPLp17-BWR1C; pleckstrin homology-like domain family A member 2; pleckstrin homology-like domain, family A, member 2; TSSC3p17-Beckwith-Wiedemann region 1C; tumor suppressing subchromosomal transferable fragment cDNA 3; tumor suppressing subtransferable candidate 3; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; tumor-supressing STF cDNA 3
Molecular Weight
Mass (kDA):
17.092 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (2928273..2929420, complement) |
Tissue Specificity
Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.
Subcellular Localizations
Cytoplasm. Membrane; Peripheral membrane protein.
Diseases
- Fetal Growth Retardation
- Benign Mixed Epithelial And Stromal Tumor Of Kidney
- Partial Hydatidiform Mole
- Hydatidiform Mole
- Cell Transformation, Neoplastic
- Complete Hydatidiform Mole
- Hypoxia
- Neoplasms
- Fetal Death
- Uterine Neoplasms
- Embryonal Carcinoma
- Malignant Neoplasm Of Brain
Pathways
- Methylation
- Dna Methylation
- Transport
- Insemination
- Pathogenesis
- Osteoclast Differentiation
- Negative Regulation Of Centriole Replication
- Negative Regulation Of Wnt Receptor Signaling Pathway
- Fertilization
- Regulation Of Gene Expression
- Ossification
- Centriole Replication
- Chondrocyte Hypertrophy
PTMs
- Methylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHLDA2
bosterbio.com/bosterbio-gene-info-cards/PHLDA2
References
PMID: 9403053 by Hu R.-J., et al. A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes.
PMID: 9328465 by Qian N., et al. The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis.