PHD finger protein 21A Antibodies

AND PHF21A ELISA kits, PHD finger protein 21A Proteins

Many biological assays use antibodies to detect PHD finger protein 21A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHD finger protein 21A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHD finger protein 21A antibodies...

We validate the specificity of these antibodies to PHD finger protein 21A by testing them on tissues known to express PHF21A positively and negatively. Browse below to find the PHF21A antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHF21A Infographic by Boster Bio

All PHF21A Products

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Specificity

Applications

Price

Anti-BHC80/PHF21A Antibody Picoband®

5 Q&As

+12

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A08507-1
100 μg/vial

PHF21A (NM_001101802) Human Over-expression Lysate

Human

$960
Cat # LS051317
100 µg

PHF21A Overview

Facts about PHD finger protein 21A.

PHF21A 3D structure. Source: alphafold

PHD finger protein 21A (PHF21A)

Part of the BHC complicated, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

In the BHC complicated, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of'Lys-4' of histone H3 in vitro, suggesting a function in demethylation regulation.

Gene Information

Human
Gene Name:	PHF21A
Uniprot:	Q96BD5
Entrez:	51317

Family

Belongs to:

No superfamily

Alternative Names

BHC80a; BHC80BM-006; BRAF35-HDAC complex protein BHC80; KIAA1696BRAF35/HDAC2 complex (80 kDa); PHD finger protein 21A

Molecular Weight

Mass (kDA):
74.854 kDA

Genomic Context


Human

Location:	11p11.2
Sequence:	11; NC_000011.10 (45929319..46121454, complement)

Tissue Specificity

Highly expressed in brain. Expressed at much lower level in other tissues.

Subcellular Localizations

Nucleus.

Diseases

Hereditary Multiple Exostoses
Haploinsufficiency
Exostoses
Chromosomal Translocation
Potocki-shaffer Syndrome
Craniofacial Abnormalities
Developmental Delay (disorder)
Muscle Hypotonia
Developmental Disabilities

Nervousness
(balanced Rearrangements Or Structural Markers Nec) Or (balanced Translocations)
Traditional Serrated Adenoma
Cytogenetic Abnormality

Interacting Proteins

BANP
FHL3
KRT40
NUP62
TRAF1

Pathways

Demethylation
Methylation
Chromatin Remodeling
Stem Cell Differentiation
Brain Development
Histone Demethylation
Establishment Of Sister Chromatid Cohesion
Chromosome Segregation
Spermatogenesis
Anaphase
Cell Division
Mrna Splicing

Sister Chromatid Cohesion
S Phase
Cell Differentiation
Chromatin Modification
Histone Methylation
Exocytosis

PTMs

Demethylation

Methylation

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHF21A

References

PMID: 12032298 by Hakimi M.-A., et al. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.

PMID: 12493763 by Hakimi M.-A., et al. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.