PHD finger protein 20 Antibodies

AND PHF20 ELISA kits, PHD finger protein 20 Proteins

Many biological assays use antibodies to detect PHD finger protein 20, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHD finger protein 20 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHD finger protein 20 antibodies...

We validate the specificity of these antibodies to PHD finger protein 20 by testing them on tissues known to express PHF20 positively and negatively. Browse below to find the PHF20 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHF20 Infographic by Boster Bio

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PHF20 Overview

Facts about PHD finger protein 20.

PHF20 3D structure. Source: alphafold

PHD finger protein 20 (PHF20)

Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4'Lys-16' acetylation (H4K16ac) amounts or locus specific histone acetylation, but rather works downstream in transcriptional regulation of MOF target genes (By similarity).

Included in the NSL complicated it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation following DNA damage.

Gene Information

Human
Gene Name:	PHF20
Uniprot:	Q9BVI0
Entrez:	51230

Family

Belongs to:

No superfamily

Alternative Names

GLEA2; PHD finger protein 20

Molecular Weight

Mass (kDA):
115.386 kDA

Genomic Context


Human

Location:	20q11.22-q11.23
Sequence:	20; NC_000020.11 (35772003..35950372)

Tissue Specificity

Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the respective normal tissues.

Subcellular Localizations

Nucleus.

Diseases

Glioblastoma
Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Lung
Glioma
Brain Neoplasms
Carcinoma
Lung Neoplasms
Non-small Cell Lung Carcinoma
Liver Carcinoma
Carcinogenesis
Adenocarcinoma
Cell Transformation, Neoplastic

Multiple Organ Failure
Genomic Instability
Malignant Tumor Of Colon
Head And Neck Carcinoma
Malignant Paraganglionic Neoplasm
Brain Tumor, Primary
Cancer Of Nasopharynx

Interacting Proteins

HIST1H3A
HIST1H4A

Pathways

Methylation
Immune Response
Cell Differentiation
Neuroendocrine Cell Differentiation
Histone Acetylation
Cell Growth

PTMs

Methylation

Phosphorylation

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHF20

References

PMID: 12097419 by Wang Y., et al. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies.

PMID: 11703362 by Fischer U., et al. Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls.