PEMT Antibodies

AND PEMT ELISA kits, PEMT Proteins

Many biological assays use antibodies to detect PEMT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PEMT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PEMT antibodies...

We validate the specificity of these antibodies to PEMT by testing them on tissues known to express PEMT positively and negatively. Browse below to find the PEMT antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PEMT Infographic by Boster Bio

All PEMT Products

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Specificity

Applications

Price

PEAMT (PEMT) (NM_007169) Human Recombinant Protein

$813
Cat # PROTQ9UBM1
20 µg

PEAMT (PEMT) (NM_148172) Human Over-expression Lysate

Human

$628
Cat # LS010400
100 µg

PEMT Overview

Facts about Phosphatidylethanolamine N-methyltransferase.

PEMT 3D structure. Source: alphafold

Phosphatidylethanolamine N-methyltransferase (PEMT)

Catalyzes the three successive steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) into phosphatidylmonomethylethanolamine (PMME), PMME into phosphatidyldimethylethanolamine (PDME), and PDME into phosphatidylcholine (PC). .

Gene Information

Human
Gene Name:	PEMT
Uniprot:	Q9UBM1
Entrez:	10400

Family

Belongs to:

class VI-like SAM-binding methyltransferase superfamily

Alternative Names

EC 2.1.1.17; PEMPTMGC2483; PEMT2PEAMT; phosphatidylethanolamine N-methyltransferase; PNMT

Molecular Weight

Mass (kDA):
22.134 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (17505561..17591987, complement)

Subcellular Localizations

[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria.; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Liver Carcinoma
Fatty Liver
Choline Deficiency
Liver Diseases
Steatohepatitis
Steatosis
Liver Neoplasms, Experimental
Neoplasms
Liver Damage
Liver Failure
Diabetes Mellitus
Obesity
5,10-methylenetetrahydrofolate Reductase Deficiency

Diabetes Mellitus, Experimental
Nonalcoholic Fatty Liver Disease
Malignant Neoplasms
Asthma
Malnutrition
Pain
Fatty Liver, Alcoholic

Pathways

Methylation
Secretion
Cdp-choline Pathway
Cell Division
Cell Proliferation
Pathogenesis
Brain Development
Cell Growth
Hepatocyte Proliferation
Cell Cycle
Localization
Cell Death
Transport

Translation
Neural Precursor Cell Proliferation
Mitosis
Dna Methylation
Excretion
Programmed Cell Death
Aging

PTMs

Methylation
Reduction
Oxidation
Phosphorylation

Nitration
Glycosylation
Cleavage
Decarboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PEMT

References

PMID: 9989271 by Walkey C.J., et al. Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2.

PMID: 11420179 by Shields D.J., et al. Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene.