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PDS5A Antibodies
AND PDS5A ELISA kits, PDS5A Proteins
Many biological assays use antibodies to detect PDS5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDS5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDS5A antibodies...
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PDS5A Infographic by Boster Bio
All PDS5A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A06272-1
100 μg/vial
Cat # A06272-1
100 μg/vial
PDS5A Overview
Facts about Sister chromatid cohesion protein PDS5 homolog A.
Sister chromatid cohesion protein PDS5 homolog A (PDS5A)
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis into DNA replication.
Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays a significant role in DNA repair. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PDS5A |
| Uniprot: | Q29RF7 |
| Entrez: | 23244 |
Family
| Belongs to: |
|---|
| PDS5 family |
Alternative Names
Cell proliferation-inducing gene 54 protein; DKFZp686B19246; FLJ41012; KIAA0648MGC131948; PDS5; PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae); PIG54; SCC-112MGC161503; Sister chromatid cohesion protein 112; sister chromatid cohesion protein PDS5 homolog A
Molecular Weight
Mass (kDA):
150.83 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p14 |
| Sequence: | 4; NC_000004.12 (39822863..39977956, complement) |
Tissue Specificity
Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.
Subcellular Localizations
Nucleus. Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Tumor Progression
- Malignant Neoplasm Of Breast
- Glioma
- Cornelia De Lange Syndrome
- Kidney Neoplasm
- Aneuploidy
- Carcinoma
- Leukemia, Myelocytic, Acute
- Megacolon
Interacting Proteins
- CDCA5
- RAD21
- SMC3
- STAG1
- STAG2
Pathways
- Cell Cycle
- Sister Chromatid Cohesion
- Chromosome Segregation
- Transport
- Cell Proliferation
- Mitosis
- Dna Repair
- Spindle Checkpoint
- Cell Death
- S Phase
PTMs
Research Areas
- Cell Cycle and Replication
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDS5A
bosterbio.com/bosterbio-gene-info-cards/PDS5A
References
PMID: 15019998 by Kumar D., et al. SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas.
PMID: 11076961 by Sumara I., et al. Characterization of vertebrate cohesin complexes and their regulation in prophase.