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- Table of Contents
Facts about PDZ and LIM domain protein 7.
Involved in both of those two basic mechanisms of bone formation, direct bone formation (e.g.
Human | |
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Gene Name: | PDLIM7 |
Uniprot: | Q9NR12 |
Entrez: | 9260 |
Belongs to: |
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No superfamily |
1110003B01Rik; ENIGMAProtein enigma; LIM domain protein; LIM mineralization protein; LMP; LMP1; PDZ and LIM domain 7 (enigma); PDZ and LIM domain protein 7
Mass (kDA):
49.845 kDA
Human | |
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Location: | 5q35.3 |
Sequence: | 5; NC_000005.10 (177483394..177497605, complement) |
Isoform 1 and isoform 2 are expressed ubiquitously, however, isoform 2 predominates in skeletal muscle, isoform 1 is more abundant in lung, spleen, leukocytes and fetal liver.
Cytoplasm. Cytoplasm, cytoskeleton. Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity).
PMID: 7929196 by Wu R.-Y., et al. LIM domain recognition of a tyrosine-containing tight turn.
PMID: 11874232 by Liu Y., et al. Overexpressed LIM mineralization proteins do not require LIM domains to induce bone.