[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (PDK2)

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis through phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate.

Inhibition of pyruvate dehydrogenase reduces glucose utilization and increases fat metabolism. Mediates cellular responses to insulin.