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PDE9A Antibodies
AND PDE9A ELISA kits, PDE9A Proteins
Many biological assays use antibodies to detect PDE9A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE9A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE9A antibodies...
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PDE9A Overview
Facts about High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A.
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A)
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814).
Specifically regulates natriuretic-peptide- dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Doesn't regulate nitric oxide-dependent cGMP in heart (PubMed:25799991).
Gene Information
| Human | |
|---|---|
| Gene Name: | PDE9A |
| Uniprot: | O76083 |
| Entrez: | 5152 |
Family
| Belongs to: |
|---|
| cyclic nucleotide phosphodiesterase family |
Alternative Names
CGMP-specific 3'-5'-cyclic phosphodiesterase type 9; CGMP-specific 3'-5'-cyclic phosphodiesterase type 9, EC 3.1.4.1710phosphodiesterase PDE9A21; EC 3.1.4.35; FLJ90181; high affinity cGMP-specific 3'-5'-cyclic phosphodiesterase 9A; HSPDE9A2; phosphodiesterase 9A
Molecular Weight
Mass (kDA):
68.493 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.3 |
| Sequence: | 21; NC_000021.9 (42653621..42775509) |
Tissue Specificity
Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood (PubMed:9624146). Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate (PubMed:12565835). In brain, present in the cortex, cerebellum, and subiculum (at protein level) (PubMed:22328573). In heart, primarily localizes to myocytes (PubMed:25799991).
Subcellular Localizations
[Isoform PDE9A1]: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum. Cell membrane, sarcolemma.; [Isoform PDE9A2]: Cell projection, ruffle membrane. Cytoplasm, perinuclear region.; [Isoform PDE9A3]: Cytoplasm. Endoplasmic reticulum.; [Isoform PDE9A17]: Cytoplasm. Endoplasmic reticulum.
Diseases
- Alzheimer's Disease
- Malnutrition
- Anemia, Sickle Cell
- Diabetes Mellitus
- Down Syndrome
- Malignant Neoplasms
- Pain
- Hereditary Diseases
- Depressive Disorder
- Impaired Cognition
- Neurodegenerative Disorders
- Nervousness
Interacting Proteins
- BAG3
- CLK1
- CRY2
- GORASP2
- KRTAP10-8
- KRTAP4-2
- KRTAP9-2
- LAGE3
- LMO2
- NAA38
Pathways
- Localization
- Cognition
- Cell Proliferation
- Sensory Processing
- Signal Transmission
- Aging
- Penile Erection
- Intracellular Signal Transduction
- Oocyte Maturation
- Cellular Localization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE9A
bosterbio.com/bosterbio-gene-info-cards/PDE9A
References
PMID: 9624146 by Fisher D.A., et al. Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase.
PMID: 9856478 by Guipponi M., et al. Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence.